CONNECTICUT CHEMOSENSORY CLINICAL RESEARCH CENTER

康涅狄格州化学传感临床研究的主要目标 研究味觉和嗅觉的功能和功能障碍 一家诊所的运营和基础广泛的多学科计划 临床和实验室研究。项目涉及来自 康涅狄格大学健康中心、医学院和牙科学院 耶鲁大学医学院和文学院 和约翰·B·皮尔斯基金会实验室。 味觉和嗅觉诊所评估主诉是 通过提供最先进的诊断和转诊进行化学检测 对那些症状无法得到帮助的人进行治疗和教育 今天的知识。所有患者都要接受化学感官测试， 耳鼻咽喉、神经学和内科检查， 实验室筛查测试，营养评估，必要时， 牙科检查。审查结果，并转介患者 治疗、额外的医学检查和/或化学感官随访。更多 到目前为止，已经看了300多名患者，我们的等待名单超过了1000人。 基础心理物理研究包括对以下方面有用的方法研究 化学感觉投诉的临床评价和描述 儿童和成人的正常化学感觉功能，以及 关于怀孕对化学感觉功能的影响的描述。研究 关于化学感觉系统的基本解剖学和生理学包括 建立嗅觉感受器投射地形图的研究 到大鼠的嗅球，并研究确定突触 孤束核的组织(将结构与功能联系起来 这是仓鼠味觉系统神经整合的第一个地点)。 这些研究工作将有助于测量化学传感的能力 功能并理解味觉、嗅觉和感官的基础 解剖、生理和经验层面的刺激。

The primary objective of the Connecticut Chemosensory Clinical Research Center is to study taste and smell function and dysfunction through the operation of a clinic and a broad-based multi-disciplinary program of clinical and laboratory research. Projects involve personnel from the University of Connecticut Health Center, Schools of Medicine and Dental Medicine, Yale University, School of Medicine and the Faculty of Arts and Sciences, and the John B. Pierce Foundation Laboratory. The Taste and Smell Clinic evaluates patients whose primary complaint is chemosensory by providing state of the art diagnosis, referrals for treatment, and education for those whose symptoms cannot be helped with today's knowledge. All patients undergo chemosensory testing, otorhinolaryngology, neurology, and internal medicine examinations, laboratory screening tests, nutritional assessment, and, as necessary, dental examination. Results are reviewed and patients are referred for treatment, additional medical tests, and/or chemosensory follow-up. More than 300 patients have been seen to date and our waiting list exceeds 1,000. Basic psychophysical research includes studies of methods useful for clinical evaluation of chemosensory complaints and the description of normal chemosensory function in children and adults, as well as a description of the effects of pregnancy on chemosensory function. Research on the basic anatomy and physiology of chemosensory systems includes studies to establish the topography of projections from olfactory receptors to the olfactory bulb in rats, and studies to determine the synaptic organization of the solitary nucleus (to relate structure to function in this first site for neural integration of the gustatory system in hamsters). These research efforts will contribute the ability to meaure chemosensory function and to understand the bases for the senses of taste, smell and irritation at anatomical, physiological and experiential levels.