University of Florida Chemosensory Clinical Research Program

佛罗里达大学化学感应临床研究项目

• 批准号: 7671411
• 负责人: FRANK A CATALANOTTO
• 金额: $ 56.3万
• 依托单位: UNIVERSITY OF FLORIDA
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-20 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7671411
• 关键词: Address; Affect; Alcohol consumption; Area; Arts; Biometry; Cardiovascular Diseases; Clinic; Clinical; Clinical Assessment Tool; Clinical Research; Collaborations; Data; Data Collection; Diet; Disease; Environment; Esthesia; Faculty; Feasibility Studies; Florida; Food; Foundations; Functional disorder; Funding; Future; Genes; Genetic; Genetic Polymorphism; Genotype; Goals; Gold; Health; Health Insurance Portability and Accountability Act; Health Services Accessibility; Human; Human Resources; Individual; Institutes; Institution; International; Ligands; Malignant Neoplasms; Marketing; Methodology; Methods; Obesity; Patients; Performance; Phase; Phenotype; Pilot Projects; Procedures; Property; Protocols documentation; Psychophysics; Psychophysiology; Recruitment Activity; Research; Research Ethics Committees; Research Infrastructure; Research Personnel; Research Project Grants; Risk Factors; Running; Scheme; Secure; Sensory; Services; Single Nucleotide Polymorphism; Smell Perception; Smoking; Speed; System; TNFRSF5 gene; Taste Perception; Technology; Testing; Time; Universities; Variant; cost; data management; data sharing; design; experience; hedonic; meetings; multicore processor; novel; patient population; programs; prototype; receptor binding; software systems; success; user-friendly; virtual; volunteer

DESCRIPTION (provided by applicant): Support is requested to establish the feasibility of and then implement four infrastructural components for the expanding Chemosensory Clinical Research Program of the University of Florida's Center for Smell and Taste. The Program focuses on the clinically important, emerging relationship between chemosensory dysfunction (taste, retronasal olfaction) and health. Variation in chemosensation (genetic or pathological) affects the sensory properties of foods as well as the sensations associated with smoking and alcohol intake. Diet, smoking, and alcohol intake are risk factors for a variety of disorders including obesity, cardiovascular disease, and some cancers. Key to understanding chemosensory variation and health is the ability to rigorously correlate the chemosensory phenotype and genotype of patient populations who suffer from these disorders. Support for the actual research to be addressed once the requested infrastructure is in place will be sought through the Institute's P50 and R01 mechanisms. We have already made significant progress in laying the foundation for the Center's Clinical Research Program. Dr. Linda Bartoshuk has joined the faculty at UF to help plan and implement clinical research projects using newly developed and appropriate psychophysical scaling methodologies. We have established the UF Taste and Smell Clinic, where a team of clinicians see patients with chemosensory complaints. We have established collaborations with the appropriate genetics, biostatistical, and marketing personnel at UF. We have had preliminary conversations with potential collaborators outside of UF to share the technologies and capabilities we develop at UF. While the University has provided modest start up funds to conduct clinical pilot projects, several of which are now underway, we lack adequate intramural funding to implement the key infrastructure required to make the Chemosensory Clinical Research Program a success. Specifically, we propose to: (1) establish a novel core dedicated to chemosensory genetics with strengths in genotyping and statistical genetics, (2) design a novel protocol using new psychophysical tools for the clinical assessment of chemosensory function (phenotype), (3) establish a novel HIPAA compliant biostatistics and data management core, and (4) establish a novel HIPAA compliant patient and subject recruitment and management core. While the Program is resident at UF, our intent is for it to function as a 'virtual center' whereby we can easily and securely share the infrastructure we generate and the research it produces with our national and international chemosensory colleagues.

描述（由申请人提供）：支持要求建立可行性，然后实施四个基础设施组件的扩展佛罗里达大学的中心化学感觉临床研究计划的味觉和味觉。该计划的重点是临床上重要的，新兴的化学感觉功能障碍（味觉，鼻后嗅觉）和健康之间的关系。化学感觉的变化（遗传或病理）影响食物的感官特性以及与吸烟和饮酒相关的感觉。饮食、吸烟和饮酒是多种疾病的危险因素，包括肥胖、心血管疾病和某些癌症。理解化学感受变异和健康的关键是能够严格关联患有这些疾病的患者群体的化学感受表型和基因型。一旦所要求的基础设施到位，将通过研究所的P50和R01机制寻求对实际研究的支持。我们已经在为中心的临床研究计划奠定基础方面取得了重大进展。琳达Bartoshuk已加入用友的教师，以帮助规划和实施临床研究项目，使用新开发的和适当的心理物理缩放方法。我们已经建立了UF味觉和味觉诊所，在那里一个临床医生团队看到患者的化学感觉投诉。我们已经建立了适当的遗传学，生物统计学和营销人员在用友合作。我们已经与用友以外的潜在合作者进行了初步对话，以分享我们在用友开发的技术和能力。虽然大学已经提供了适度的启动资金进行临床试点项目，其中几个现在正在进行中，我们缺乏足够的校内资金来实施所需的关键基础设施，使Chemosensory临床研究计划取得成功。具体而言，我们建议：（1）建立一个致力于化学感受遗传学的新核心，具有基因分型和统计遗传学方面的优势，（2）使用新的心理物理学工具设计一个新的方案，用于化学感受功能（表型）的临床评估，（3）建立一个新的符合HIPAA的生物统计学和数据管理核心，以及（4）建立一个新的符合HIPAA的患者和受试者招募和管理核心。虽然该计划是在UF居民，我们的意图是它作为一个“虚拟中心”，使我们可以轻松，安全地分享我们产生的基础设施和研究它产生与我们的国家和国际chemosensory同事。