CENTER FOR RESEARCH ON FERTILITY AND INFERTILITY

这个P-30中心核心补助金申请是一个直接的产物， 在过去十年中发展的十个教师的研究需求 在西北大学从事生殖研究， 生育和不育的领域。 这十个调查员 目前拥有21个由NIH/NIMH资助的研究赠款/项目， 获得5个科学核心;其中12个赠款/项目由 NICHD。 P-30中心核心补助金所服务的研究项目 包括对生殖的神经内分泌学的研究， 性腺功能的调节机制， 配子发生，卵泡选择机制 生殖激素的作用，调节生殖器的机制， 轨道功能和免疫机制调节生育能力。 拟议的P-30中心核心补助金的调查人员目前正在 在生物化学， 分子、细胞、生理和行为水平。 的复杂性 当今生殖研究领域的生命科学需要 分享技术和方法，而这些技术和方法往往是 一个研究实验室。 事实上，很明显， 我们对生殖系统理解的突破 需要具有专业知识的研究人员的合作努力， 不同的研究领域。 这五个方面，就是要建立一个 科学核心，使核心研究人员能够将 他们的研究项目中， 成本效益的方式。 此外，核心将提供质量 控制和技术专长，在一些不同的技术， 这一水平通常不适用于个别研究者。 五 科学核心将作为P-30核心中心赠款的一部分建立 是西北大学的研究人员确定的 最大的需求，这将对质量产生最大的影响， 这所大学的生殖研究。 待建立的核心 是分子技术，蛋白质分析，原位 杂交、单克隆抗体-细胞培养和激素和 神经递质测量。 行政核心也将是 为管理中心补助金而设立。 设立这一 P-30中心核心补助金将提高质量和成本效益 现有的联邦资助的生殖研究项目 科学，并预计将导致更好地了解 生育和不育的调节机制。

This P-30 Center Core Grant application is a direct outgrowth of the research needs that have developed over the past decade of ten faculty at Northwestern University who are engaged in reproductive research in the areas of fertility and infertility. These ten investigators currently hold 21 funded NIH/NIMH research grants/projects that will access 5 scientific cores; 12 of these grants/projects are funded by the NICHD. The research programs to be served by the P-30 Center Core Grant include investigations into the neuroendocrinology of reproduction, the regulatory mechanisms of gonadal functions, the regulatory mechanisms of gametogenesis, the mechanisms of follicular selection, the ,mechanisms of action of reproductive hormones, the mechanisms regulating genital track functions and he immunological mechanisms regulating fertility. Investigators in the proposed P-30 Center Core Grant are currently addressing questions in the reproductive sciences at the biochemical, molecular, cellular, physiological and behavioral levels. The complexity of the life sciences in the area of reproductive research today requires the sharing of techniques and approaches that are often not available in a single research laboratory. Indeed, it is clear that major breakthroughs in our understanding of the reproductive system will require collaborative efforts of researchers who have expertise in diverse areas of research. Thus, this grant seeks to establish five scientific Cores which will enable Core investigators to incorporate highly sophisticated techniques into their research programs in a cost-effective manner. Furthermore, the Cores will provide quality control and technical expertise in a number of different techniques at a level normally not available to individual Investigators. The five scientific Cores to be established as part of the P-30 Core Center Grant were those that Northwestern investigators determined were in the greatest need and that would have the greatest impact on the quality of reproductive research at this University. The Cores to be established are those for Molecular Technology, Protein Analysis, In situ Hybridization, Monoclonal Antibody-Cell Culture, and Hormone and Neurotransmitter Measurements. An Administrative Core will also be established to administer the Center Grant. The establishment of this P-30 Center Core Grant will enhance the quality and cost-effectiveness of existing federally-funded research programs in the reproductive sciences, and is anticipated to lead to a better understanding of the regulatory mechanisms underlying fertility and infertility.