SYNCHROTRON X-RAY MICROPROBE FACILITY

同步加速器 X 射线显微镜设施

• 批准号: 3104016
• 负责人: KEITH W JONES
• 金额: $ 26.62万
• 依托单位: ASSOCIATED UNIV-BROOKHAVEN NATL LAB
• 依托单位国家: 美国
• 财政年份: 1984
• 资助国家: 美国
• 起止时间: 1984-06-01 至 1987-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3104016
• 关键词: X ray; biomedical equipment resource; electron probe spectrometry; electron radiation; particle beam; trace elements

It is proposed to operate a Biotechnology Research Center using high-energy x-rays produced by the National Synchrotron Light Source (NSLS) for trace element analysis in a number of biomedical fields. The uniquely high x-ray intensity from the NSLS will be used as the basis of an X-Ray Microprobe Facility which will be able to provide a highly polarized photon flux of about 10 to the 15 photons/square centimeters/sec in a spot of size 2 mm x 2mm. With use of high resolution electron and photon spectrometers multielement detection for essentially all elements in the periodic table will be possible with sensitivities close to one part per billion by weight in times of 5 minutes or less for each sample. A two-dimensional demagnification system will be used to provide focussed spots of 20 Mum or less with similar detection sensitivities. The properties of this system will be investigated to determine the ultimate sensitivities and spatial resolutions that can be obtained. Round-robin studies will be carried out to compare this technique with other analytical methods and to demonstrate its unique features. Studies on selected biomedical topics will be carried out on a collaborative basis.

建议使用高能量的生物技术研究中心 国家同步加速器光源（NSLS）产生的X射线， 元素分析在许多生物医学领域。 独特的高X射线 来自NSLS的强度将用作X射线微探针的基础 该设施将能够提供高度偏振的光子通量， 在尺寸为2 mm × 10 mm的光斑中约10到15个光子/平方厘米/秒 2毫米。 使用高分辨率电子和光子光谱仪 用于周期表中基本上所有元素的多元素检测 将有可能与敏感性接近十亿分之一的重量 每个样品的时间为5分钟或更短。 二维 将使用缩小系统提供20 μ m的聚焦点，或 较少具有相似的检测灵敏度。 这个系统的性质 将进行调查，以确定最终的敏感性和空间 可以获得的解决方案。 将进行循环研究 将该技术与其他分析方法进行比较， 其独特的功能。 将进行选定生物医学主题的研究 在合作的基础上。