SYNCHROTRON X-RAY MICROPROBE FACILITY

同步加速器 X 射线显微镜设施

• 批准号: 3104012
• 负责人: KEITH W JONES
• 金额: $ 40.42万
• 依托单位: ASSOCIATED UNIV-BROOKHAVEN NATL LAB
• 依托单位国家: 美国
• 财政年份: 1984
• 资助国家: 美国
• 起止时间: 1984-06-01 至 1990-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3104012
• 关键词: X ray; biomedical equipment resource; electron probe spectrometry; electron radiation; fluorescence; particle beam; toxicology; trace elements

The Brookhaven Synchrotron X-Ray Microprobe Research Resource uses high-energy x-rays produced by the National Synchrotron Light Source (NSLS) for sensitive trace-element analysis and imaging in various types of biological structures. The NSLS is a uniquely bright source of x-rays and thereby serves as the foundation of the Resources which is presently unsurpassed at any other location. The aim of the Resource is to combine scientists from the life and physical sciences in a multidisciplinary effort to push the potentialities of synchrotron radiation for elemental x-ray fluorescence measurements to (1) the furthest possible limits in terms of sensitivity, spatial resolutions, and chemical form of the elements examined and (2) to carry on an extensive biological research program to exploit the results of the technical development program. Other Brookhaven nuclear facilities are used to complement the features of the photon beams at the NSLS so as to provide other nuclear analytical techniques when necessary. The complete facility fills the gap between high resolution electron microscopy and bulk analysis techniques. The combination of the synchrotron with computed tomography techniques extends the possibilities of tomography into many new research regions. This Resource uses radiation from a bending magnet to provide filtered white light or monochromatic radiation. The addition of focussing mirrors to the system will give higher fluxes at the target and increase the sensitivity of the determinations. Two different types of mirrors are planned: a simple 1:1 cylindrical mirror and an 8:1 ellipsoidal mirror which focusses in two dimensions. The goal is to obtain detection sensitivities less than 50-100 ppb (by weight) in a 10- to 20-magnetic moment. The Resource presently can be used with a spot size of 25 magnetic moment, and a detection sensitivity around 200 ppb for elements around iron. The initial biological research effort is aimed at studying several aspects of trace element biology and toxicology: (1) trace element localization in the hepatic lobule, (2) trace element interactions, (3) trace element analysis of rodent cerebellium, (4) sterological analysis of microprobe data, and (5) in-vivo analysis of lead in the tibia. A number of collaborative projects in related analytical and biological fields are in progress with scientists from other institutions. A service program is operated to make sure that the Resource can be used freely by all qualified and interested scientists. The new features of the Resource are made known by a regular series of workshops and symposia and seminars presented by the Resource staff.

布鲁克海文同步辐射X射线微探针研究 资源使用国家生产的高能X射线 用于敏感痕量元素的同步辐射光源 分析和成像在各种类型的生物结构。 的 NSLS是一种独特的明亮的X射线源，因此可以作为 资源的基础，这是目前无与伦比的， 任何其他位置。 资源的目的是将联合收割机 来自生命科学和物理科学领域的科学家， 推动同步加速器潜力的多学科努力 用于元素x射线荧光测量的辐射（1） 在灵敏度、空间 决议，和化学形式的元素检查和（2） 进行广泛的生物学研究计划， 技术开发项目的成果。 其他 布鲁克海文核设施用于补充 NSLS的光子束特征，以便提供其他 必要时进行核分析。 完整的 该设备填补了高分辨率电子显微镜 和批量分析技术。 同步加速器 计算机断层扫描技术扩展了 断层扫描进入许多新的研究领域。 此资源使用 来自偏转磁体的辐射以提供过滤的白色光，或者 单色辐射 增加聚焦镜， 该系统将在目标处给出更高的通量， 测定的灵敏度。 两种不同类型的镜子 一个简单的1：1柱面镜和一个8：1椭圆面镜 在两个维度上聚焦的镜子。 我们的目标是获得 检测灵敏度小于50-100 ppb（按重量计），在10至 20-磁矩 资源目前可以与 25磁矩的光斑尺寸和检测灵敏度 大约200 ppb的铁元素。 初始生物 研究工作的目的是研究几个方面的痕迹 元素生物学和毒理学：（1）微量元素在 肝小叶，（2）微量元素相互作用，（3）微量 啮齿类动物小脑的元素分析，（4）小脑的体视学分析， 微探针数据，和（5）胫骨中铅的体内分析。 一 相关分析和技术领域的合作项目数目 生物学领域正在与来自其他领域的科学家合作， 机构职能体系 运行服务程序以确保 资源可供所有合格和感兴趣的人免费使用 科学家 资源的新功能通过以下方式公布： 定期举办一系列讲习班、专题讨论会和研讨会 资源工作人员介绍。