Representation and Incorporation of Fossil Data in Molecular Dating of Species Divergences

化石数据在物种分歧分子测年中的表示和结合

• 批准号: BB/G006660/1
• 负责人: Philip Donoghue
• 金额: $ 4.36万
• 依托单位: University of Bristol
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2009
• 资助国家: 英国
• 起止时间: 2009 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=BB%2FG006660%2F1
• 关键词: Representation; Incorporation; Fossil; Data; Molecular

If our genes accumulate changes over time at a constant rate, the genetic distance between two species, measured by the number of changes accumulated, will be proportional to the time of species divergence. Thus molecules can serve as a clock, keeping time of species divergence by the accumulated changes. If fossil records or geological events can be used to assign an absolute geological time to a species divergence event on the phylogenetic tree, one can convert all calculated genetic distances into absolute geological times. This rationale for molecular clock dating has recently been extended to deal with local variation in evolutionary rate. Critical to molecular dating is the use of fossil information to calibrate the clock. In this project, we will develop statistical models and computer algorithms to accurately represent and incorporate fossil calibration information in molecular dating analysis. We will also implement models that explicitly consider errors in fossil calibrations. The new methods will be applied to analyze large sequence datasets to estimate divergence times among primates and vertebrates.

如果我们的基因随着时间以恒定的速度累积变化，两个物种之间的遗传距离(以累积的变化数量衡量)将与物种分化的时间成正比。因此，分子可以作为时钟，通过累积的变化来记录物种分化的时间。如果化石记录或地质事件可以用来为系统发育树上的物种分化事件分配绝对地质时间，人们就可以将所有计算出的遗传距离转换为绝对地质时间。这种分子时钟测年的原理最近已经扩展到处理进化速度的局部变化。分子测年的关键是使用化石信息来校准时钟。在这个项目中，我们将开发统计模型和计算机算法，以准确地表示和纳入分子测年分析中的化石校准信息。我们还将实施明确考虑化石校准误差的模型。新方法将被应用于分析大型序列数据集，以估计灵长类和脊椎动物之间的分歧时间。

项目成果

Uncertainty in the Timing of Origin of Animals and the Limits of Precision in Molecular Timescales.

• DOI: 10.1016/j.cub.2015.09.066
• 发表时间: 2015-11-16
• 期刊: Current biology : CB
• 作者: dos Reis M;Thawornwattana Y;Angelis K;Telford MJ;Donoghue PC;Yang Z
• 通讯作者: Yang Z

Constraining the timing of whole genome duplication in plant evolutionary history.

• DOI: 10.1098/rspb.2017.0912
• 发表时间: 2017-07-12
• 期刊: Proceedings. Biological sciences
• 作者: Clark JW;Donoghue PCJ
• 通讯作者: Donoghue PCJ

Constraining uncertainty in the timescale of angiosperm evolution and the veracity of a Cretaceous Terrestrial Revolution.

• DOI: 10.1111/nph.15011
• 发表时间: 2018-04
• 期刊: The New phytologist
• 作者: Barba-Montoya J;Dos Reis M;Schneider H;Donoghue PCJ;Yang Z
• 通讯作者: Yang Z