SCOR--RESPIRATORY DISORDERS IN NEONATES AND CHILDREN

SCOR--新生儿和儿童呼吸系统疾病

• 批准号: 3106391
• 负责人: MILDRED T STAHLMAN
• 金额: $ 121.7万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-12-30 至 1996-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3106391
• 关键词: bronchopulmonary dysplasia; infant human (0-1 year); lung; newborn human (0-6 weeks); respiratory distress syndrome of newborn

Bronchopulmonary dysplasia (BPD) has become the greatest contributor to morbidity in newborn intensive care units. BPD is the clinical consequence of lung injury in the human newborn infant that occurs when functional integrity of the lung is not restored in a timely and orderly manner by the repair process. With a focus on BPD in mind, the goals of this SCOR relate to lung development at the level of cell growth and differentiation, to mechanisms of defense against lung injury, and to repair processes that are initiated in response to lung injury. This SCOR also addresses mechanisms by which clinical interventions can be employed to modify either lung injury or the repair process as a strategy to reduce the incidence and severity of BPD. Finally, in anticipation that the rapidly growing success of lung transplantation will inevitably be extended to the infant with end- stage BPD, this SCOR will attempt to answer questions related to the surfactant system in the transplanted lung, both in regard to performance of the surfactant system in the denervated lung and in regard to the role of surfactant treatment during episodes of rejection. Specific projects in this proposed SCOR involve studies of 1) epidermal growth factor signal transduction in the developing lung, 2) the role of extracellular matrix biosynthesis in fetal rat lung epithelial cell growth and differentiation, 3) the role of pulmonary surfactant associated proteins and related C-type lectins in the lung development, injury and repair, 4) the effects of vitamin A on the regulation of lung epithelial differentiation, 5) the regulation of P450 gene expression and its role in oxidant production by the hyperoxic lung, and 6) the physiologic effects of surfactant treatment in human premature infants. Resources to support these projects are provided by five cores: the Newborn clinical Research Core, the Animal Laboratory Core, the Biomedical Engineering and Informatics Core, the Histopathology and Molecular Biology Core, and the Administrative Core.

支气管肺发育不良（BPD）已成为最大的致病因素 新生儿重症监护病房的发病率。 BPD 是临床结果 人类新生婴儿功能正常时发生的肺损伤 肺部的完整性没有及时有序地恢复 修复过程。 考虑到 BPD 的重点，此 SCOR 的目标涉及 在细胞生长和分化水平上促进肺发育 防御肺损伤的机制，并修复 为应对肺损伤而启动。 该 SCOR 还涉及机制 通过临床干预可以用来改变任一肺 损伤或修复过程作为减少发生率的策略 BPD 的严重程度。 最后，预计快速增长的成功 肺移植的范围将不可避免地扩展到患有终末期婴儿 阶段 BPD，此 SCOR 将尝试回答与 移植肺中的表面活性剂系统，无论是在性能方面 表面活性剂系统在去神经肺中的作用及其作用 排斥反应期间的表面活性剂治疗。 具体项目在 该提议的 SCOR 涉及 1) 表皮生长因子信号的研究 发育中肺的转导，2) 细胞外基质的作用 胎鼠肺上皮细胞生长和分化中的生物合成， 3）肺表面活性物质相关蛋白及相关C型的作用 凝集素在肺发育、损伤和修复中的作用，4) 维生素A对肺上皮分化的调节，5) P450基因表达的调控及其在氧化剂产生中的作用 高氧肺，以及 6) 表面活性剂治疗的生理效应 在人类早产儿中。 支持这些项目的资源是 由五个核心提供：新生儿临床研究核心、动物 实验室核心、生物医学工程和信息学核心、 组织病理学和分子生物学核心，以及行政核心。