CRC/PE FOR THE STUDY OF ALZHEIMER'S DISEASE

虽然最近在这方面做了大量工作， 认知功能障碍的临床和生物学特征 AD的精神症状很少受到关注。 克利夫兰大学医院/凯斯西校区（University Hospitals of Cleveland/Case Western） 储备大学（UHC/CWRU）阿尔茨海默病临床研究 中心（ACRC），我们将描述认知和精神 症状的人群AD患者，遵循他们 纵向，并探讨改变之间的关系， 肾上腺素能和肾上腺素能标记物在生命和死亡中， 临床特征。 该ACRC的目标是为以下方面做出贡献： 更好地理解认知的生物学基础 和行为表现，这将导致更好的 诊断和治疗方法。 这一目标将通过六个核心来实现：临床， 临床药理学神经影像学，神经病理学，数据 管理和分析，以及行政。 核心将 作为ACRC调查人员的资源，以及 UHC/CWRU的其他研究人员。 全面诊断 认知和精神疾病的治疗方法 AD的表现显然需要生物学和 行为方面。 包括五个具体的研究项目 在建议中：1）生化评估的β-肾上腺素能和 血小板中的去甲肾上腺素能标记物，2） 肾上腺素能和肾上腺素能系统调节皮质醇 分泌和糖皮质激素受体数量，3）死后 皮质、肾上腺素能和肾上腺素能结合的改变 部位，4）描述蓝斑的病理学， 中缝核; 5）血脑的神经控制研究 屏障监管 此外，机制具体 包括在ACRC评估新的研究提案 由UHC/CWRU调查员生成。

Although considerable work has been performed recently on the clinical and biological features of the cognitive impairment of AD, little attention has been paid to the psychiatric symptoms. In the proposed University Hospitals of Cleveland/Case Western Reserve University (UHC/CWRU) Alzheimer Clinical Research Center (ACRC), we will characterize cognitive and psychiatric symptoms of a population of AD patients, follow them longitudinally, and explore the relationships between alterations in adrenergic and serotonergic markers in life and in death with the clinical features. The goal of this ACRC is to contribute to a better understanding of the biological basis of the cognitive and behavioral manifestations of AD, which will lead to better diagnostic and therapeutic approaches. This goal will be accomplished through six cores: Clinical, Clinical Pharmacology Neuroimaging, Neuropathology, Data Management and Analysis, and Administrative. The cores will serve as a resource for investigators in the ACRC, as well as other investigators at UHC/CWRU. A comprehensive diagnostic and therapeutic approach to the cognitive and psychiatric manifestations of AD obviously requires both biological and behavioral aspects. Five specific research projects are included in the proposal: 1) biochemical assessment of serotonergic and noradrenergic markers in blood platelets, 2) the role of adrenergic and serotonergic systems in the regulation of cortisol secretion and glucocorticoid receptor number, 3) post mortem alterations in cortical, adrenergic, and serotonergic binding sites, 4) description of the pathology of the locus coeruleus and raphe nucleii, and 5) studies of the neural control of blood-brain barrier regulation. In addition, mechanisms are specifically included in the ACRC to evaluate new research proposals generated by UHC/CWRU investigators.