UHC/CWRU ALZHEIMERS DISEASE RESEARCH CENTER

拟议的阿尔茨海默病研究中心(ADRC)将是 以现有的个人专业知识和机构承诺为基础 对阿尔茨海默病(AD)的研究，临床护理 患者，以及有关这方面的知识的传播 毁灭性的混乱。克利夫兰大学医院和 凯斯西储大学(CWRU)支持阿尔茨海默病中心 协调研究、临床护理和教育项目 在公元后。我们建议的ADRC将研究功能重要性 阿尔茨海默病发生的异常从分子生物学到 日常生活活动。重点将放在 了解不同级别的 科学研究，即信使RNA的变化如何与 细胞功能障碍；细胞功能障碍与认知能力的关系 认知功能障碍如何转化为功能性功能障碍 残疾？拟议的ADRC将围绕五个核心进行组织： 1)行政，2)临床(包括患者登记表和 数据管理和分析部分)、3)研究培训和 信息传输核心(教育核心)，4)成像核心，以及 5)神经病理核心。将增加三个研究项目 已经存在的研究计划：1)大脑的血管 衰老与AD(Harik/Kalaria)，2)AD中淀粉样蛋白的特征 杨金(Young Kin)，3)阿尔茨海默病(AD)功能性沟通功能衰退(Ripich)。在……里面 此外，我们提出了几个试验性研究项目，这些项目将 建立在我们已经存在的试点拨款研究计划的基础上。 建议在第一年进行的研究包括：免疫染色指纹 神经组织(Caplan)、PHF结合蛋白(Perry)和 社会期望反应倾向与照顾者负担(Smyth)。 第二年的建议包括：医生的态度和做法 对阿尔茨海默病患者(Kahana)、ADL技能和认知状态的研究 (Martin)，AD中的高级视觉功能(Mendez)，以及Black和 老年痴呆症患者的白人照顾者(Wykle/Segall)。 拟议的ADRC将允许一个已经具有凝聚力的、全国性的 公认的调查小组将继续进行重大调查 对理解这种障碍的贡献，将这种 对改进临床护理的认识和教育层面 团体、专业人士和政策制定者--包括当地和 全国--关于这种毁灭性的疾病。

The proposed Alzheimer's Disease Research center (ADRC) will be built on existing individual expertise and institutional commitment to the study of Alzheimer's disease (AD), clinical care of patients, and the dissemination of knowledge concerning this devastating disorder. University Hospitals of Cleveland (UHC) and Case Western Reserve University (CWRU) support an Alzheimer Center that coordinates research, clinical care, and educational programs in AD. Our proposed ADRC will examine the functional importance abnormalities occurring in AD ranging from molecular biology to activities of daily living. Emphasis will be placed on understanding inter-relationships between different levels of scientific inquiry, i.e. how do changes in messenger RNA relate to cell dysfunction; how does cell dysfunction relate to cognitive impairment; and how does cognitive impairment convert to functional disability? The proposed ADRC will be organized around five cores: 1) Administrative, 2) Clinical (including a patient registry and a data management and analysis component), 3) Research Training and Information Transfer Core (Education Core), 4) Imaging Core, and 5) Neuropathology Core. Three research projects will be added to the already existing research program: 1) Vessels of the Brain Aging and AD (Harik/Kalaria), 2) Characterization of Amyloid in AD (Younkin), 3) Functional Communication Decline in AD (Ripich). In addition, we propose several pilot research projects which will be built on our already existing pilot grant research program. Studies proposed for year one include: Immunostain Fingerprints of the Neural Tissue (Caplan), PHF Binding Proteins (Perry), and Socially Desirable Response Tendency and Caregiver Burden (Smyth). Second year proposal include: Physicians' Attitudes and Practices toward AD Patients (Kahana), ADL skills and Cognitive Status in AD (Martin), Higher Visual Functions in AD (Mendez), and Black and White Caregivers of Elders with Dementia (Wykle/Segall). The proposed ADRC will permit an already cohesive, nationally recognized group of investigators to continue making major contributions to understanding this disorder, converting this understanding into improved clinical care, and educating lay groups, professionals, and policy makers--both locally and nationally--concerning this devastating disease.