COMPREHENSIVE SICKLE CELL CENTER

综合性镰状细胞中心

• 批准号: 3108464
• 负责人: CHARLES F WHITTEN
• 金额: $ 83.95万
• 依托单位: WAYNE STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1977
• 资助国家: 美国
• 起止时间: 1977-04-01 至 1993-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3108464
• 关键词: comprehensive care; human subject; sickle cell anemia

In this project a group of basic, clinical and social scientists will investigate aspects of sickle cell disease and provide a service program for individuals with sickle cell conditions. The research projects are designed to answer the following questions. Is the clinical severity of Sickle-B Thalassemia related to the molecular defect? What are the key DNA segments and the trans factors that regulate the expression of globin genes? What is the relationship between the rheological properties of sickle cells and sickle cell membranes to clinical status, hemolysis rate, and cation transport mechanism? What is the immunological basis for age-dependent and type specific variations in antibody response to pneumococcal polysaccharide antigens? What are the factors that govern the rate of sickling and desickling? What is the nature and mechanism of abnormalities of cell mediated immune function in zinc deficient sickle cell anemia patients? What is the effect of zinc supplementation on growth and development of zinc deficient individuals who have sickle cell anemia? What are the social factors and coping processes related to adjustment of school-aged children with sickle cell anemia? The service programs are designed: to inform the Black population about sickle cell conditions and to motivate those in the child bearing age to seek testing; counsel those who are identified as having sickle cell trait so that they can make informed self interest decisions; to permit mothers who are pregnant with a child with sickle cell anemia to make informed self interest decisions with respect to continuing or terminating the pregnancy; and to prevent premature death in young children with sickle cell anemia from pneumococcal sepsis and acute splenic sequestration.

在这个项目中，一组基础，临床和社会科学家 将研究镰状细胞疾病的各个方面，并提供 针对患有镰状细胞状况的人的服务计划。 这 研究项目旨在回答以下问题。 是镰状-B thalassya的临床严重程度与 分子缺陷？ 什么是关键的DNA段和反式 调节球蛋白基因表达的因素？ 是什么 镰状细胞的流变特性之间的关系 和镰状细胞膜达到临床状况，溶血率和 阳离子运输机制？ 什么是免疫学基础 年龄依赖性和类型的特异性变化在抗体反应中 肺炎球菌多糖抗原？ 有什么因素 管理邪恶和令人沮丧的速度？ 什么是自然和 细胞介导的免疫功能异常的机理 缺乏镰状细胞贫血患者？ 锌的影响是什么 补充锌不足的生长和发展 患有镰状细胞贫血的人？ 什么是社交 因素和应对过程与调整学龄有关 患有镰状细胞贫血的孩子？ 设计计划的设计：通知黑人人口 关于镰状细胞状况并激励孩子中的人 轴承年龄寻求测试；咨询那些被确定为 具有镰状细胞性状，以便他们可以使知情自我 利息决定；允许怀有孩子的母亲 用镰状细胞贫血做出明智的自我利益决定 关于继续或终止怀孕；然后 防止幼儿过早死亡 肺炎球菌和急性脾脏的镰状细胞贫血 隔离。