OLFACTORY MODEL OF BRAIN AGING

大脑老化的嗅觉模型

• 批准号: 3116376
• 负责人: FOTEOS MACRIDES
• 金额: $ 11.54万
• 依托单位: WORCESTER FOUNDATION FOR BIOMEDICAL RES
• 依托单位国家: 美国
• 财政年份: 1985
• 资助国家: 美国
• 起止时间: 1985-08-01 至 1988-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3116376
• 关键词: aging; animal old age; behavior test; brain electrical activity; catecholamines; cognition disorders; dementia; discrimination learning; disease /disorder model; ethology; follicle stimulating hormone; histochemistry /cytochemistry; immunochemistry; luteinizing hormone; neurochemistry; neuroendocrine system; olfactions; olfactory lobe; prolactin; sensory discrimination; serotonin; sex behavior; testosterone

The proposed research seeks to capitalize upon the extensive morphological and functional interconnections among olfactory, limbic and basal forebrain structures in rodents to develop an advantageous model for studies of aging in the mammalian central nervous system. Neurochemical changes in limbic and cholinergic basal forebrain structures with which the olfactory system is directly connected have been implicated as etiological factors in mnemonic and cognitive impairments that sometimes occur with aging, and more severe atrophic changes in these structures and connections may account for debilitating symptoms of Alzheimer's disease. An interrelated series of psychophysical, behavioral, electrophysiological, endocrinological, biochemical and immunohistochemical analyses is proposed to examine the effects of aging changes in these structures and connections on cognitive and mnemonic aspects of olfactory information processing. Through these analyses we hope to lay the groundwork for research on cellular and neurochemical mechanisms of brain aging.

拟议的研究旨在利用广泛的形态学 以及嗅觉、边缘系统和基底前脑之间的功能联系 啮齿类动物的结构，以开发一个有利的模型，用于研究衰老 在哺乳动物的中枢神经系统中。 边缘系统的神经化学变化 和胆碱能基底前脑结构，嗅觉系统 直接相关的疾病， 记忆和认知障碍，有时会发生与老化，和 这些结构和连接中更严重的萎缩性变化可能 导致老年痴呆症的衰弱症状 相互联系 一系列的心理生理，行为，电生理， 内分泌，生化和免疫组织化学分析提出 研究这些结构和连接的老化变化的影响， 嗅觉信息处理的认知和记忆方面的研究。 通过这些分析，我们希望为以下研究奠定基础： 脑老化的细胞和神经化学机制。