OLFACTORY MODEL OF BRAIN AGING

大脑老化的嗅觉模型

• 批准号: 3116378
• 负责人: FOTEOS MACRIDES
• 金额: $ 10.19万
• 依托单位: WORCESTER FOUNDATION FOR BIOMEDICAL RES
• 依托单位国家: 美国
• 财政年份: 1985
• 资助国家: 美国
• 起止时间: 1985-08-01 至 1988-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3116378
• 关键词: aging; animal old age; behavior test; brain electrical activity; catecholamines; cognition disorders; dementia; discrimination learning; disease /disorder model; ethology; follicle stimulating hormone; gonadotropins; hippocampus; histochemistry /cytochemistry; immunochemistry; luteinizing hormone; neurochemistry; neuroendocrine system; olfactions; olfactory lobe; prolactin; sensory discrimination; serotonin; sex behavior; testosterone

The proposed research seeks to capitalize upon the extensive morphological and functional interconnections among olfactory, limbic and basal forebrain structures in rodents to develop an advantageous model for studies of aging in the mammalian central nervous system. Neurochemical changes in limbic and cholinergic basal forebrain structures with which the olfactory system is directly connected have been implicated as etiological factors in mnemonic and cognitive impairments that sometimes occur with aging, and more severe atrophic changes in these structures and connections may account for debilitating symptoms of Alzheimer's disease. An interrelated series of psychophysical, behavioral, electrophysiological, endocrinological, biochemical and immunohistochemical analyses is proposed to examine the effects of aging changes in these structures and connections on cognitive and mnemonic aspects of olfactory information processing. Through these analyses we hope to lay the groundwork for research on cellular and neurochemical mechanisms of brain aging.

拟议的研究旨在利用广泛的形态学 以及嗅觉、边缘系统和基底前脑之间的功能互连 啮齿类动物的结构以开发用于衰老研究的有利模型 在哺乳动物的中枢神经系统中。 边缘系统的神经化学变化 和胆碱能基底前脑结构，嗅觉系统 直接相关已被认为是病因因素 有时随着年龄的增长而出现记忆和认知障碍，以及 这些结构和连接的更严重的萎缩性变化可能 解释阿尔茨海默病的衰弱症状。 一个相互关联的 系列心理物理学、行为学、电生理学、 建议进行内分泌、生化和免疫组织化学分析 检查这些结构和连接的老化变化的影响 关于嗅觉信息处理的认知和记忆方面。 通过这些分析，我们希望为以下方面的研究奠定基础： 大脑衰老的细胞和神经化学机制。