NEUROBEHAVIORAL STUDIES OF ALCOHOL TOLERANCE

酒精耐受性的神经行为研究

• 批准号: 3109467
• 负责人: MICHAEL J LEWIS
• 金额: $ 9.03万
• 依托单位: HOWARD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1984
• 资助国家: 美国
• 起止时间: 1984-01-01 至 1987-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3109467
• 关键词: 6 hydroxydopamine; arginine vasopressin; behavior; brain electrical activity; brain electronic stimulator; dissection; dopamine; drug tolerance; ethanol; histology; molecular psychobiology; naloxone; neurochemistry; neurohormones; neuropharmacology; neurotoxins; neurotransmitters; norepinephrine; radiotracer; scintillation counter; stimulus /response; thin layer chromatography; tryptamines

The research proposed here will investigate neurobehavioral determinants of ethanol (ETOH) tolerance and the reinforcing effects of ETOH. Determination of the effects of chronic injection of ETOH on brain stimulation reward (BSR) at several brain sites of rats will be made. Three parameters of BSR will be measured simultaneously at each brain site: threshold of reward, rate of response and average brain impedance. A behavioral research design which permits determination of "learned" vs "unlearned" tolerance will be employed. Experiments are designed to 1. systematically investigate acute and chronic ETOH administration at specific brain loci, 2. determine learned and unlearned tolerance effects on BSR at each site, 3. investigate monoaminergic neuro-transmitter systems in learned and unlearned tolerance, and 4. examine the role of selected neurohormone systems in learned and unlearned tolerance. With time permitting, additional investigations of conditioning factors in both tolerance, other neuro-transmitters and neuropeptides, and other drugs which are "cross-tolerant" with ETOH will be investigated. The proposed studies are behavioral (psychological), pharmacological and biochemical. They should collectively shed important light on ETOH tolerance reinforcement produced by ETOH and brain sites which mediate these effects.

这里提出的研究将调查神经行为的决定因素