Microdialysis/Neurotransmitters/Alcohol Reinforcement

微透析/神经递质/酒精强化

• 批准号: 6585378
• 负责人: MICHAEL J LEWIS
• 金额: $ 5.63万
• 依托单位: PRINCETON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-02-01 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6585378
• 关键词: acetylcholine; alcoholism /alcohol abuse; behavioral /social science research tag; dopamine; dosage; ethanol; gamma aminobutyrate; glutamates; hypothalamus; injection /infusion; laboratory rat; microdialysis; motivation; neurochemistry; neuropharmacology; neuropsychology; neurotransmitters; nucleus accumbens; psychobiology; psychological reinforcement; psychophysiology; self medication; tegmentum

DESCRIPTION (provided by applicant): The research will provide an examination of four key neurotransmitters (GABA, glutamate, dopamine, and acetylcholine) that are believed to play important roles in alcohol behavioral effects and motivational behaviors. The unique value in the proposed research fellowship is that it will provide state of the art training in neurochemical techniques for the measurement of the extracellular concentrations of each neurotransmitter and to measure two and potentially all concurrently. Measurement will be to determine the effects of injection and self-administration of alcohol. The research will provide new information about the role of these neurotransmitters in alcohol abuse and alcoholism.

描述（由申请人提供）：该研究将提供对四种关键神经递质（GABA，谷氨酸，多巴胺和乙酰胆碱）的检查，这些神经递质被认为在酒精行为效应和动机行为中起重要作用。拟议的研究奖学金的独特价值在于，它将提供神经化学技术的最新培训，用于测量每种神经递质的细胞外浓度，并同时测量两种和可能的所有神经递质。测量将确定注射和自我给药酒精的影响。这项研究将为这些神经递质在酒精滥用和酒精中毒中的作用提供新的信息。