ETHANOL EFFECTS ON CNS TISSUE IN VITRO

酒精暴露对中枢神经系统功能的影响将是 在体外脑切片中使用细胞内记录进行研究。 研究 将重点关注与酒精相关的基因变异， 行为以及动物耐受和依赖乙醇， 慢性给药 本研究项目的长期目标 是三重的。 首先，电生理反应的机制， 乙醇将被表征为直接的、调节的或涉及局部的 回路中间神经元 第二，遗传变异和耐受/依赖 动物将允许乙醇诱导的电生理反应， 与酒精诱导的行为有关。 最后，乙醇的作用 将研究代谢物和缩合产物。 更大 了解急性乙醇暴露如何改变中枢神经系统功能， 对酒精中毒问题的新见解

The effects of ethanol exposure on central nervous system function will be pursued using intracellular recording in the in vitro brain slice. Studies will focus on genetic variants manifesting differential alcohol-related behaviors as well as animals made tolerant and dependent on ethanol by chronic administration. The long-term objectives of this research program are threefold. First, the mechanism of electrophysiological responses to ethanol will be characterized as direct, modulatory or involving local circuit interneurons. Second, the genetic variants and tolerant/dependent animals will permit ethanol-induced electrophy-siological responses to be correlated with alcohol-induced behaviors. Finally, the role of ethanol metabolites and condensation products will be investigated. A greater understanding of how acute ethanol exposure alters CNS function may furnish new insights into the problem of alcohol intoxication.