EFFECT OF FETAL EXPOSURE TO ALCOHOL ON AGING

胎儿接触酒精对衰老的影响

• 批准号: 3111459
• 负责人: BYRON A CAMPBELL
• 金额: $ 11.99万
• 依托单位: PRINCETON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1988
• 资助国家: 美国
• 起止时间: 1988-03-01 至 1992-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3111459
• 关键词: aging; alcoholic beverage consumption; animal age group; animal developmental psychology; attention deficit disorder; auditory threshold; autonomic nervous system; behavior; behavior disorders; blood chemistry; central nervous system; developmental neurobiology; developmental psychology; electrodes; embryo /fetus drug adverse effect; ethanol; fear; fetal alcohol syndrome; heart rate; laboratory rat; longevity; longitudinal animal study; pain; postnatal growth disorder; prenatal stress; reflex; sensorimotor system; sensory disorders; visual threshold

The major purpose of the proposed research will be to study the effects of fetal alcohol exposure on aging and longevity. A subsidiary goal will be to investigate several potentially important sequelae of fetal alcohol exposure that have not been examined by previous researchers. These include the effects of prenatal alcohol on sensory function, autonomic function, and attention. The primary concern of the proposed research is the effect of prenatal alcohol exposure on aging. Is the lifespan of the fetal alcohol animal reduced and, if so, by how much? Second, does the fetal alcohol syndrome include, as one of its hidden or overlooked symptoms, either generalized accelerated aging of the central nervous system or selective accelerated aging of specific neural and/or behavioral systems? Third, how long do the behavioral effects of fetal alcohol exposure last? Which, if any, persist throughout the animals' lifespan? And, finally, do any of the deficits or abnormalities that disappeared (recovered) during development of early adulthood, reappear during the course of normal aging? The experimental plan of the proposed research is to maintain pregnant Fischer 344 rats on a liquid diet containing 35% alcohol derived calories day 6 post-conception until the day before parturition. Following parturition the animals will be tested periodically on battery of behavioral tasks designed to trace the emergence during development and the decline during senescence of simple motor and reflexive behaviors, sensory thresholds, sensory-motor integrity, attentional processes and autonomic reactivity.

拟议研究的主要目的将是研究 胎儿酒精暴露对衰老和寿命的影响。一个 次要目标将是调查几个潜在的重要 未经检查的胎儿酒精暴露后遗症 之前的研究人员。这些包括产前的影响。 酒精对感觉功能、自主神经功能和注意力的影响。 这项拟议研究的主要问题是 胎儿期酒精暴露对衰老的影响。是胎儿的寿命 酒精动物减少了，如果是的话，减少了多少？其次， 胎儿酒精综合征包括，作为其隐藏或被忽视的一种 症状，要么是广泛性的中枢加速衰老 神经系统或特定神经的选择性加速老化 和/或行为系统？第三，多长时间的行为 胎儿酒精暴露的最后影响是什么？如果有的话，它会持续存在 在动物的整个生命周期里？最后，做任何 在此期间消失(恢复)的缺陷或异常 成年期早期的发育，在 正常衰老吗？ 拟议研究的实验计划是维持 Fischer 344孕鼠以含35%酒精的液体饲料喂养 受孕后第6天至怀孕前一天的衍生卡路里 分娩。分娩后，将对动物进行测试 周期性地执行一系列旨在跟踪 发育中的涌现和衰老中的衰退 简单的运动和反射行为，感觉阈值， 感觉-运动完整性、注意过程和自主神经 反应性。