EFFECT OF FETAL EXPOSURE TO ALCOHOL ON AGING

胎儿接触酒精对衰老的影响

• 批准号: 3111457
• 负责人: BYRON A CAMPBELL
• 金额: $ 11.36万
• 依托单位: PRINCETON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1988
• 资助国家: 美国
• 起止时间: 1988-03-01 至 1992-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3111457
• 关键词: aging; alcoholic beverage consumption; animal age group; animal developmental psychology; attention deficit disorder; auditory threshold; autonomic nervous system; behavior; behavior disorders; blood chemistry; central nervous system; developmental neurobiology; developmental psychology; electrodes; embryo /fetus drug adverse effect; ethanol; fear; fetal alcohol syndrome; heart rate; laboratory rat; longevity; longitudinal animal study; pain; postnatal growth disorder; prenatal stress; reflex; sensorimotor system; sensory disorders; visual threshold

The major purpose of the proposed research will be to study the effects of fetal alcohol exposure on aging and longevity. A subsidiary goal will be to investigate several potentially important sequelae of fetal alcohol exposure that have not been examined by previous researchers. These include the effects of prenatal alcohol on sensory function, autonomic function, and attention. The primary concern of the proposed research is the effect of prenatal alcohol exposure on aging. Is the lifespan of the fetal alcohol animal reduced and, if so, by how much? Second, does the fetal alcohol syndrome include, as one of its hidden or overlooked symptoms, either generalized accelerated aging of the central nervous system or selective accelerated aging of specific neural and/or behavioral systems? Third, how long do the behavioral effects of fetal alcohol exposure last? Which, if any, persist throughout the animals' lifespan? And, finally, do any of the deficits or abnormalities that disappeared (recovered) during development of early adulthood, reappear during the course of normal aging? The experimental plan of the proposed research is to maintain pregnant Fischer 344 rats on a liquid diet containing 35% alcohol derived calories day 6 post-conception until the day before parturition. Following parturition the animals will be tested periodically on battery of behavioral tasks designed to trace the emergence during development and the decline during senescence of simple motor and reflexive behaviors, sensory thresholds, sensory-motor integrity, attentional processes and autonomic reactivity.

拟议研究的主要目的是研究 胎儿酒精暴露对衰老和寿命的影响。 一 次要目标将是调查几个潜在的重要 胎儿酒精暴露的后遗症，尚未检查 以前的研究人员。 这些包括产前的影响， 酒精对感觉功能、自主神经功能和注意力的影响。 拟议研究的主要关注点是 产前酒精暴露对衰老的影响 是胎儿的寿命 酒精动物减少，如果是，减少多少？ 第二，※ 胎儿酒精综合征包括，作为其隐藏或忽视的一个 症状，无论是普遍加速老化的中央 神经系统或特定神经系统的选择性加速老化 和/或行为系统 第三，行为多久 胎儿酒精暴露的影响会持续多久 如果有的话， 在动物的一生中？ 最后，做任何 缺陷或异常消失（恢复）期间 在成年早期的发展过程中， 正常老化？ 拟议研究的实验计划是维持 妊娠Fischer 344大鼠，喂食含35%酒精的流质食物 从受孕后第6天到受孕前一天 分娩 分娩后，将对动物进行试验 定期进行一系列行为任务， 在发育过程中出现，在衰老过程中衰退 简单的运动和反射行为，感觉阈值， 感觉运动完整性、注意力过程和自主神经 反应性