ALCOHOL DEPENDENCE: PSYCHOIMMUNOLOGY AND AIDS RISK

酒精依赖：心理免疫学和艾滋病风险

• 批准号: 3112194
• 负责人: STEVEN J SCHLEIFER
• 金额: $ 51.8万
• 依托单位: UNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL
• 依托单位国家: 美国
• 财政年份: 1990
• 资助国家: 美国
• 起止时间: 1990-08-01 至 1995-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3112194
• 关键词: AIDS; AIDS /HIV test; alcoholism /alcohol abuse; behavior modification; belief; clinical depression; disease /disorder proneness /risk; health behavior; high risk behavior /lifestyle; human subject; immunologic assay /test; longitudinal human study; psychological stressor; psychological tests; psychoneuroimmunology; sex behavior; social perception; urban poverty area

There is increasing evidence that psychosocial processes influence the immune system and that these effects may contribute to the onset and course of disease. These factors, especially stress and depression, are common in alcohol dependent persons and, together with the direct effects of alcohol may seriously compromise immune function in this population. Alcohol use is also associated with behavioral disinhibition that can increase high risk behaviors linked to the transmission of HIV. The co-occurrence of these factors in alcoholics may pose a substantial public health threat. The implications of these interactions are particularly serious in inner city settings where the prevalence of HIV is high. Research is therefore urgently needed to understand factors that may contribute to the spread of HIV in high risk groups such as inner city alcoholics. The overall goal of the proposed research is to investigate the psychoimmunology of inner city alcoholics at risk for AIDS by: 1. comparing immune function in inner city alcohol-dependent subjects with that of matched controls; 2. assessing the immune effects of specific characteristics of alcoholics, including alcohol use, stress and depression; and, 3. concurrently assessing high risk behaviors for HIV transmission and the determinants of such behaviors. 150 alcohol-dependent patients enrolled in an ambulatory alcohol treatment program who have not abused other substances and 150 matched study controls will be studied utilizing both a cross-sectional and longitudinal study design. Patients with medical disorders, compromised hepatic function, positive for HIV-1 antibody, or using other medications or drugs will be excluded. Subjects will be interviewed concerning patterns of alcohol use, life stress, and depression, screening physical examinations and chemistries will be obtained, and blood drawn for a battery of in vitro immune measures. High risk sexual behaviors for HIV transmission and HIV attitudes, beliefs and peer norms will be documented. Subjects and controls will be re-assessed at 1 and 3 months. Multivariate techniques will analyze the psychoimmunologic and other behavioral relationships.

越来越多的证据表明心理社会过程影响 免疫系统，这些影响可能会导致发病和病程 的疾病。 这些因素，尤其是压力和抑郁，在 酒精依赖者，以及酒精的直接影响 可能会严重损害该人群的免疫功能。 饮酒 也与行为去抑制有关，可以增加高 与艾滋病毒传播相关的危险行为。 The co-occurrence of 酗酒者的这些因素可能对公共健康构成重大威胁。 这些相互作用对内在的影响尤其严重。 艾滋病毒流行率较高的城市环境。 Research is therefore 迫切需要了解可能导致病毒传播的因素 内城酗酒者等高危人群中的艾滋病毒感染者。 拟议研究的总体目标是调查 通过以下方式对内城酗酒者进行艾滋病风险的心理免疫学研究： 1. 比较内城区酒精依赖受试者的免疫功能 匹配控制的控制； 2. 评估特定的免疫效果 酗酒者的特征，包括饮酒、压力和 沮丧; 3. 同时评估艾滋病毒高危行为 传播以及此类行为的决定因素。 150 名酒精依赖患者参加了流动酒精治疗 未滥用其他物质的计划和 150 个匹配的研究对照 将利用横断面和纵向研究进行研究 设计。 患有内科疾病、肝功能受损的患者， HIV-1 抗体呈阳性，或使用其他药物或药物将 排除。 受试者将接受有关饮酒模式的采访， 生活压力、抑郁症、筛查体检和 将获得化学物质，并抽取血液用于体外电池 immune measures. 艾滋病毒传播和艾滋病毒的高危性行为 态度、信仰和同伴规范将被记录下来。 Subjects and 控制措施将在 1 个月和 3 个月时重新评估。 多元技术 将分析心理免疫学和其他行为关系。