权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

MAJOR DEPRESSIVE DISORDER AND IMMUNE FUNCTION

重度抑郁症与免疫功能

基本信息

批准号：
3377549
负责人：
STEVEN J SCHLEIFER
金额：
$ 20.38万
依托单位：
MOUNT SINAI SCHOOL OF MEDICINE OF CUNY
依托单位国家：
美国
项目类别：
财政年份：
1984
资助国家：
美国
起止时间：
1984-09-01 至 1987-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/3377549
关键词：
B lymphocyte T lymphocyte cellular immunity cortisol helper T lymphocyte hormone regulation /control mechanism human subject humoral immunity immunofluorescence technique immunoregulation leukocyte activation /transformation neuroendocrine system phagocytosis radiotracer suppressor T lymphocyte tissue /cell culture

项目摘要

The applicants have been investigating associations between clinical depression and immunity. This research, which has been supported by the NIMH Small Grants Program, 1 R03 MH 37774-01MSMB, demonstrated that responses to T cell and T-dependent B cell mitogens as well as the absolute number of lymphocytes and T and B cells were significantly lower in drug free hospitalized patients with major depressive disorder than in apparently healthy matched controls. We also found that a group of less severely depressed outpatients with major depressive disorder had no changes in mitogen responses but did have a decrease in the number of lymphocytes and that hospitalized schizophrenics did not differ from matched controls on any of the immune measures. These findings suggest that depression is associated with altered immune function. The proposed research will investigate whether altered immunity is specific to the state of being depressed and if it is related to severity of the illness. Immune function will therefore be assessed in drug free patients with mild and severe depressive disorders compared with matched controls during depression and in clinical remission. Studies of alterations of immunity in depression may provide information about underlying neurobiological processes in depressive states. The immune changes may be related to other biological systems which can influence the lymphocyte and other immunocompetent and immunoregulatory cells. Neuroendocrine function and specifically cortisol secretion will therefore be investigated in relation to altered immunity in depressed patients. To further elucidate the biological processes which may link depression and the immune system, a comprehensive investigation of immunity will be undertaken, including: antigen as well as mitogen responses, T-independent B cell mitogen responses, numbers of T, T helper, T suppressor and B lymphocytes, natural killer cell function, and phagocyte activity. These studies may help to elucidate the pathophysiology of depressive states manifested in patterns of dysregulation of neurotransmitter, neuroendocrine and immune systems. The investigation of specific alterations in the immune system of depressives and their behavioral and neurobiological correlates may also provide a biologic basis for precise diagnosis of affective diseases as well as of risk factors. The findings may ultimately suggest strategies for intervention and treatment of depression.

申请人一直在调查临床抑郁症和免疫力这项研究得到了 NIMH小额赠款项目，1 R 03 MH 37774- 01 MSMB，证明了对T细胞和T依赖性B细胞有丝分裂原的反应以及绝对淋巴细胞、T细胞和B细胞的数量在药物组中显著降低，免费住院的抑郁症患者比健康的对照组。我们还发现，一组重度抑郁症门诊患者没有有丝分裂原反应的变化，但确实有数量减少，淋巴细胞和住院精神分裂症患者没有不同，所有免疫指标都与对照组相匹配这些发现表明抑郁症与免疫功能改变有关拟议研究将调查改变的免疫力是否是国家特有的抑郁症是否与疾病的严重程度有关。免疫因此，将在无药物的轻度和重度抑郁症与对照组相比，抑郁症和临床缓解。对抑郁症免疫力改变的研究可能提供信息抑郁状态下潜在的神经生物学过程。的免疫变化可能与其他生物系统有关，影响淋巴细胞和其他免疫活性和免疫调节细胞神经内分泌功能，特别是皮质醇分泌，因此，研究与抑郁症患者免疫力改变的关系，患者为了进一步阐明生物学过程抑郁症与免疫系统、免疫力的全面考察将进行，包括：抗原以及有丝分裂原反应， T细胞非依赖性B细胞有丝分裂原反应，T细胞、辅助性T细胞、抑制和B淋巴细胞、自然杀伤细胞功能和吞噬细胞活动这些研究可能有助于阐明抑郁状态表现为神经功能失调模式神经递质、神经内分泌和免疫系统。调查抑郁症患者免疫系统的特异性改变及其行为和神经生物学的相关性也可能提供生物学基础用于情感疾病和风险因素的精确诊断。研究结果最终可能会提出干预策略，抑郁症的治疗