MODERATE DRINKING AND CORONARY HEART DISEASE MORTALITY

适量饮酒与冠心病死亡率

• 批准号: 3112442
• 负责人: DOUGLAS C COATE
• 金额: $ 7.68万
• 依托单位: NATIONAL BUREAU OF ECONOMIC RESEARCH
• 依托单位国家: 美国
• 财政年份: 1990
• 资助国家: 美国
• 起止时间: 1990-07-01 至 1991-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3112442
• 关键词: alcoholic beverage consumption; blood pressure; cardiovascular disorder epidemiology; coronary disorder; diet; health related legal; health surveys; human mortality; legal /correctional; lifestyle; nutrition related tag; sex; socioeconomics

The objective of the proposed research is to investigate the relationship between moderate drinking and coronary heart disease (CHD) mortality. A large number of autopsy, ecologic, case-control, and cohort studies have reported a U shaped relationship between moderate drinking and CHD mortality, with alcoholic beverage consumption in the one to four drinks per day range being associated with lower rates of mortality than lower and higher rates of consumption. If this relationship is causal and runs from moderate drinking to improved coronary health, an added level of complexity may characterize the formulation of alcoholic beverage excise tax policy. The data sets proposed for the research are the National Health and Nutrition Examination Survey, 1971-74, and the National Health and Nutrition Examination Follow-up Survey, 1982-84. Specific questions addressed in the research include: Is the statistical association between moderate drinking and CHD mortality explained by a correlation with confounding variables such as income, education, diet, or lifestyle that actually underlie the relationship but have not been controlled for in previous studies? Does the statistical association between moderate drinking and CHD mortality hold up across different socioeconomic, age, and sex groups? Does the direction of causality in the moderate drinking-CHD relationship run form moderate drinking to improved CHD health or from good health to moderate drinking?

拟议研究的目的是调查两者之间的关系 适度饮酒与冠心病（CHD）死亡率之间的关系。 一个 大量尸检、生态学、病例对照和队列研究 据报道，适量饮酒与冠心病之间存在 U 形关系 死亡率，饮酒一到四杯的酒精饮料 每天的范围与较低的死亡率相关 更高的消费率。 如果这种关系是因果关系并且来自 适量饮酒可改善冠状动脉健康，增加复杂性 可能会体现酒精饮料消费税政策的制定。 为该研究提出的数据集是国家卫生和 营养检查调查，1971-74 年，以及国家健康和 营养检查跟踪调查，1982-84。 具体问题 研究中涉及的问题包括： 适度饮酒与冠心病死亡率的相关性可解释为 收入、教育、饮食或生活方式等混杂变量 实际上是这种关系的基础，但并未受到控制 以前的研究？ 中等程度之间是否存在统计关联？ 饮酒和冠心病死亡率在不同的社会经济、年龄和文化背景下都存在差异 性别群体？ 适度饮酒与冠心病的因果关系方向吗 适度饮酒与改善冠心病健康或良好的健康关系 健康要适量饮酒？