MUTATIONAL VARIATION IN LIFE HISTORIES

本项目将评估由于新的- 在果蝇中出现的突变，关于一些 几种不同的生活史特征，包括年龄- 特定雌性生殖力，特定年龄雄性交配成功率， 寿命、生存能力和净适应性。 突变将被 积累在第二条染色体上， 选择. 其目的是检验衰老部分是 由于有害突变的积累， 仅限于晚年，通过确定是否有一个 突变变异的显著部分是年龄特异性的， 这是这个理论所要求的。 突变变异的本质 将与保持不变的变化进行比较， 早期的研究表明， 在不同年龄的影响。 基因突变率 控制生活史字符将被估计为一部分， 本研究

This project will assess the nature of variation due to newly- arisen mutations in Drosophila, with respect to a number of several different life-history characteristics including age- specific female fecundity, age-specific male mating success, longevity, viability, and net fitness. Mutations will be accumulated on second chromosomes maintained free of selection. The aim is to test the theory that senescence is in part due to the accumulation of deleterious mutations with effects confined to late in life, by determining whether or not a significant fraction of mutational variation is age-specific in the way required by this theory. The nature of mutational variation will be compared with that maintained as standing variation, where earlier studies have suggested negative correlations between effects at different ages. Rates of mutation for genes controlling life-history characters will be estimated as part of this study.