MUTATIONAL VARIATION IN LIFE HISTORIES

本项目将评估由于新的- 在果蝇中出现突变，涉及到一些 几种不同的生活史特征，包括年龄- 特定的雌性繁殖力，特定年龄的雄性交配成功， 长寿、生存能力强、身体健康。突变将是 积累在第二条染色体上，保持自由 选择。其目的是检验衰老在一定程度上 由于有害突变的积累产生了影响 仅限于晚年，通过确定一个 很大一部分突变变异是特定于年龄的 这一理论所要求的方法。突变变异的本质 将与保持为常态变化的情况进行比较， 早期的研究表明负相关性 在不同年龄的影响之间。基因突变率 控制生活史角色将被估计为 这项研究。

This project will assess the nature of variation due to newly- arisen mutations in Drosophila, with respect to a number of several different life-history characteristics including age- specific female fecundity, age-specific male mating success, longevity, viability, and net fitness. Mutations will be accumulated on second chromosomes maintained free of selection. The aim is to test the theory that senescence is in part due to the accumulation of deleterious mutations with effects confined to late in life, by determining whether or not a significant fraction of mutational variation is age-specific in the way required by this theory. The nature of mutational variation will be compared with that maintained as standing variation, where earlier studies have suggested negative correlations between effects at different ages. Rates of mutation for genes controlling life-history characters will be estimated as part of this study.