BEHAVIORAL AND PHYSIOLOGICAL BIOMAKERS OF AGING

衰老的行为和生理生物制造者

• 批准号: 3118992
• 负责人: DAVID S OLTON
• 金额: $ 16.06万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1988
• 资助国家: 美国
• 起止时间: 1988-04-01 至 1998-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3118992
• 关键词: aging; animal old age; behavior test; biological models; biomarker; blood glucose; dietary control; early experience; gender difference; genetic strain; glucose tolerance test; juvenile animal; laboratory mouse; laboratory rat; learning; longitudinal animal study; mature animal; nutrition of aging; nutrition related tag; psychomotor reaction time; sensorimotor system; short term memory; visual perception

Experiments will develop a battery of test for four different classes of biomarkers of aging: Sensory and motor function, learning and memory, reproductive function, neuroendocrine function. For each biomarker, two strains of mice and two strains of rats will be tested in a series of preliminary experiments designed to establish the most effective task parameters to detect age-related changes in the biomarker at different chronological ages. The performance of diet-restricted and ad libitum fed animals will assess the effects of this manipulation, which increases longevity, on behavioral and physiological functions. The data analysis will provide measures of reliability and validity, and assess different theoretical descriptions of aging of processes. The most reliable and valid procedures will be combined into a test battery that can be administered to an animal to assess the four classes of biomarkers. A cross-sectional between-subjects design will assess the interrelationship of the different biomarkers, and a longitudinal, within-subjects design will assess the predictability of the biomarker profile at one age for the profile at a subsequent age, and the interrelationship between the rates of change in the different biomarkers.

实验将为四种不同的测试开发一组测试 衰老生物标志物的类别：感觉和运动功能， 学习记忆，生殖功能，神经内分泌 功能 对于每种生物标志物，两种小鼠和两种小鼠 将在一系列的初步实验中进行测试 旨在建立最有效的任务参数， 在不同的时间检测生物标志物中与年龄相关的变化， 实际年龄 饮食限制和ad的表现 自由进食的动物将评估这种操作的效果， 在行为和生理上， 功能协调发展的 数据分析将提供可靠性措施 和有效性，并评估不同的理论描述老化 的过程。 最可靠和有效的程序将被合并成一个 测试组合，其可以施用于动物以评估 四类生物标志物。 受试者间的横断面研究 设计将评估不同的 生物标志物和纵向受试者内设计将评估 在一个年龄的生物标志物谱的可预测性， 在随后的年龄，以及之间的相互关系， 不同生物标志物的变化率。