RELATIONSHIP OF AGING, FEVER AND CELL MEDIATED IMMUNITY

衰老、发烧和细胞介导的免疫之间的关系

• 批准号: 3115831
• 负责人: THOMAS Toyokazu YOSHIKAWA
• 金额: $ 7.24万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 1985
• 资助国家: 美国
• 起止时间: 1985-02-01 至 1989-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3115831
• 关键词: aging; animal age group; dietary trace element; hyperthermia; nutrition related tag; pyrogens; tissue /cell culture; zinc

The objectives of this research proposal are to determine (a) how advancing age diminishes fever response, (b) whether the integrity of fever response is related to the integrity of cell-mediated immunity, and (c) whether nutritional factors such as zinc deficiency contribute to blunted fever responses associated with age. Elderly persons have a higher prevalence of infectious diseases and suffer greater morbidity and mortality from infectious complications. Moreover, elderly patients with infections have atypical clinical manifestations of infections, particularly fever. Fever is frequently blunted or absent in the presence of infection in this population. The research proposal attempts to investigate this phenomenon and understand its pathogenetic mechanism. The project will evaluate fever responses in young and old mice by injecting endogenous pyrogen extracted from peritoneal macrophages of young and old mice. The fever responses will also be correlated with in vitro testing of cell-mediated immune functions. Finally, young and old mice will be made zinc deficient and evaluated for fever responses to endogenous pyrogens.

这项研究提案的目标是确定(A)如何推进 年龄使发热反应减弱，(B)发热反应是否完整 与细胞免疫的完整性有关，以及(C)是否 缺锌等营养因素会导致钝性发热 与年龄相关的反应。 老年人的传染病患病率较高，并患有 感染性并发症的发病率和死亡率更高。此外， 老年感染患者具有不典型的临床表现 感染，尤其是发烧。发烧经常钝化或消失。 在这群人中感染的存在。研究方案 试图研究这一现象并了解其发病机制 机制。 该项目将通过以下方式评估小鼠和老年鼠的发烧反应 注射从幼鼠腹腔巨噬细胞中提取的内源性热原 还有老老鼠。发烧反应也将与体外试验相关 检测细胞介导的免疫功能。最后，小白鼠和老白鼠 将导致缺锌，并评估内源性发热反应 热源。

项目成果

Interrelationship of fever, immune response and aging in mice.

小鼠发烧、免疫反应和衰老的相互关系。

• DOI: 10.1016/0047-6374(94)01543-u
• 发表时间: 1995
• 期刊: Mechanisms of ageing and development
• 影响因子: 5.3
• 作者: Norman,DC;Castle,S;Yamamura,RH;Yoshikawa,TT
• 通讯作者: Yoshikawa,TT

Aging decreases beta-endorphin enhancement of T-cell mitogenesis in mice.

衰老会降低小鼠 T 细胞有丝分裂的 β-内啡肽增强作用。

• DOI: 10.1016/0047-6374(88)90090-5
• 发表时间: 1988
• 期刊: Mechanisms of ageing and development
• 影响因子: 5.3
• 作者: Norman,DC;Morley,JE;Chang,MP
• 通讯作者: Chang,MP

Fever response in old and young mice after injection of interleukin 1.

注射白细胞介素1后老年和年轻小鼠的发烧反应。

• DOI: 10.1093/geronj/43.4.m80
• 发表时间: 1988
• 期刊: Journal of gerontology
• 作者: Norman,DC;Yamamura,RH;Yoshikawa,TT
• 通讯作者: Yoshikawa,TT

Fever and aging: central nervous system prostaglandin E2 in response to endotoxin.

发烧与衰老：中枢神经系统前列腺素 E2 对内毒素的反应。

• DOI: 10.1016/0531-5565(87)90003-9
• 发表时间: 1987
• 期刊: Experimental gerontology
• 影响因子: 3.9
• 作者: Grahn,D;Norman,DC;Yoshikawa,TT
• 通讯作者: Yoshikawa,TT