RELATIONSHIP OF AGING, FEVER AND CELL MEDIATED IMMUNITY

本研究计划的目的是确定（a）如何推进 年龄降低发热反应，（B）发热反应是否完整 与细胞介导的免疫的完整性有关，以及（c）是否 缺锌等营养因素导致钝热 与年龄相关的反应。 老年人传染病发病率较高， 感染并发症的发病率和死亡率更高。 此外，委员会认为， 老年感染者有不典型的临床表现， 感染，尤其是发烧。 发烧往往是钝或不存在， 这一人群中感染的存在。 研究建议 试图探讨这一现象并了解其发病机制 机制 该项目将通过以下方式评估年轻和年老小鼠的发热反应： 从腹腔巨噬细胞中提取的内源性致热原 老老鼠 发热反应也将与体外 测试细胞介导的免疫功能。 最后，年轻和年老的老鼠 将使其缺锌，并评价对内源性 热原

The objectives of this research proposal are to determine (a) how advancing age diminishes fever response, (b) whether the integrity of fever response is related to the integrity of cell-mediated immunity, and (c) whether nutritional factors such as zinc deficiency contribute to blunted fever responses associated with age. Elderly persons have a higher prevalence of infectious diseases and suffer greater morbidity and mortality from infectious complications. Moreover, elderly patients with infections have atypical clinical manifestations of infections, particularly fever. Fever is frequently blunted or absent in the presence of infection in this population. The research proposal attempts to investigate this phenomenon and understand its pathogenetic mechanism. The project will evaluate fever responses in young and old mice by injecting endogenous pyrogen extracted from peritoneal macrophages of young and old mice. The fever responses will also be correlated with in vitro testing of cell-mediated immune functions. Finally, young and old mice will be made zinc deficient and evaluated for fever responses to endogenous pyrogens.