IMMUNITY TO PARASITIC INFECTION

对肠道寄生线虫的后天防御机制， 旋毛虫将在大鼠和小鼠身上进行分析，以期确定 快速排出的机制及其影响因素的遗传因素 寄主对感染的抗性的发展和表达。有两个刺激因素 在大鼠体内充分表达快速排出所需。这其中的一个 由成虫提供的刺激似乎缺乏免疫学特异性； 然而，需要更确凿的证据来证实这一观点。这个 上述刺激物可能与刺激(炎症)有关 肠壁将在使用各种抑制剂的实验中进行检查 炎症，如水杨酸盐、肾上腺皮质类固醇、消炎痛和 眼镜蛇毒素中裂解C3的因子。 对快速排泄反应的遗传学研究将在小鼠身上进行。它有 已经证明，表达快速驱逐的能力是作为一种遗传的 显性特征。计划进行回交实验，以测试 认为响应性是由内在基因或基因传递的命题 与H-2复合体密切相关。如果事实证明是这样的话， 基因图谱将在使用同基因小鼠和重组菌株的实验中进行。

Acquired defense mechanisms against the intestinal dwelling nematode, Trichinella spiralis, will be analyzed in rats and mice with a view to defining the mechanism of rapid expulsion and genetic factors that influence the development and expression of host resistance to infection. Two stimuli are required for the full expression of rapid expulsion in rats. One of these stimuli, provided by adult worms, seems to lack immunological specificity; however, more rigourous evidence is needed to substantiate this notion. The possibility that the above stimulus is related to irritation (inflammation) of the intestinal wall will be examined in experiments using various inhibitors of inflammation, such as salicylates, adrenal corticosteroids, indomethacin, and the factor in cobra venom which cleaves C3. Genetic studies of the rapid expulsion response will be pursued in mice. It has been shown that the capacity to express rapid expulsion is inherited as a dominant characteristic. Back cross experiments are planned to test the proposition that responsiveness is transferred by a gene that lies within or is closely linked to the H-2 complex. If this should prove to be the case, the gene would be mapped in experiments using congenic mice and recombinant strains.