FAT AND FAT-FREE BODY COMPOSITION DEVELOPMENT IN AGING

衰老过程中的脂肪和无脂肪身体成分发展

• 批准号: 3120182
• 负责人: RICHARD A BOILEAU
• 金额: $ 12.93万
• 依托单位: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN
• 依托单位国家: 美国
• 财政年份: 1988
• 资助国家: 美国
• 起止时间: 1988-12-01 至 1992-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3120182
• 关键词: aging; body composition; body water; electrophysiology; fat body; growth /development; human middle age (35-64); human old age (65+); longitudinal human study; middle childhood (6-11); nutrition related tag; photoelectron spectrometry; photon absorptiometry; physical fitness; young adult human (21-34)

Body composition assessment is an important aspect in evaluating health, nutritional status and physical fitness. The proposed research is designed to investigate methodological approaches to assess body composition throughout the life-cycle and to provide normative data on children and older adults which presently is unavailable. In the first aspect of the program, both cross-sectional and longitudinal research designs will be used to extend previous work on children and to initiate new, but related, research focusing on body composition and the adult aging process. Previous research has demonstrated that the fat-free body (FFB) composition varies substantially due to changes in water and bone mineral content during pediatric growth and development. Moreover, there is evidence, although sparse, that the FFB composition changes during he adult aging proces. Two studies are proposed to investigate the integrity of assumptions associated with FFB constancy. The first will follow high and low physically active children (age 10-13 years) longitudinally over four years to validate and extend our past findings based on normal children with respect to growth changes in FFB composition. The second study will investigate change in FFB composition during the adult aging process utilizing a cross-sectional design in a large sample of males and females, 20-70 years of age. To study the constancy of the FFB, a previously developed methodological approach will be utilized involving measures of density (hydrostatic weighing), total body water (deuterium oxide dilution, bone mineral content (photon absorptiometry), and body potassium (40K count). A second aspect of the proposed research program on body composition methodology is the development of measurement techniques which can be applied in clinical examinations and large field studies. Several studies are proposed to investigate the precision with which anthropometric and bioelectric techniques (total body electromagnetic conductivity and whole body electrical resistance) can estimate fat and FFB: 1) a large cross- sectional sample of males and females ages 10-70 years; 2) longitudinal studies to determine the precision of estimating body composition changes during growth and aging; and 3) a study to assess the usefulness of these techniques to measure changes during weight gain and loss. The research plan has been revised to longitudinally study the precision with which anthropometric and bioelectric techniques can track change in body composition during growth and aging. Dual photon absorptiometry has been added to measure total body bone mineral.

身体成分评估是评估健康的一个重要方面， 营养状况和身体健康。 拟议的研究是 旨在研究评估身体状况的方法 在整个生命周期的组成，并提供规范性数据， 儿童和老年人，目前还没有。 上 该计划的方面，包括横向和纵向研究 设计将用于扩展以前的儿童工作，并启动 新的，但相关的，研究重点是身体成分和成人 老化过程 之前的研究表明，无脂肪的身体 (FFB)由于水和骨骼的变化， 矿物质含量在儿童生长发育过程中的作用。 而且 有证据表明，虽然稀疏，FFB组成的变化， 成年衰老过程 提出了两项研究，以调查 与FFB恒定性相关的假设的完整性。 第一个将 跟踪高和低体力活动儿童（10-13岁） 纵向超过四年来验证和扩展我们过去的研究结果 基于正常儿童FFB的生长变化 混合物. 第二项研究将调查FFB成分的变化 在成人老化过程中， 大样本的男性和女性，20-70岁。 研究 FFB的恒定性，以前开发的方法学方法将 使用涉及密度测量（静水称重）、总量 身体水分（氧化氘稀释，骨矿物质含量（光子 吸收测定法）和体钾（40 K计数）。 的第二方面 建议的身体成分方法学研究计划是 开发可应用于临床的测量技术 考试和大型实地考察。 提出了几项研究， 研究人体测量和生物电测量的精确度 技术（全身电磁传导率和全身 电阻）可以估计脂肪和FFB：1）一个大的交叉- 年龄在10-70岁之间的男性和女性的截面样本; 2）纵向 确定估计身体成分变化的精确度的研究 在生长和衰老过程中;和3）一项研究，以评估这些有用的 测量体重增加和减少期间变化的技术。 研究 计划已被修订，以纵向研究的精度， 人体测量和生物电技术可以跟踪身体的变化， 在生长和衰老过程中。 双光子吸收测定法已被 测量全身骨矿物质含量。