BIOLOGY OF LEISHMANIA IN PHLEBOTOMINE SANDFLIES

这个项目的目的是研究人类的生物学。 致病性利什曼原虫在它们的血吸虫沙蝇媒介中。这个 该项目涉及寄生虫学、医学 昆虫学、遗传学、病毒学、生物化学和免疫学。 实验室饲养的沙蝇将被实验感染， 利什曼病的一些不同类型和以下几个方面 寄生虫在昆虫生物学中的作用将被研究： 糖类在促进或抑制利什曼病感染中的作用 鸡血对沙蝇体内寄生虫感染的影响 媒介，沙蝇媒介能力的遗传基础， 沙蝇后肠道和尾部的生化和形态研究 它在勒传播中的作用。Braziliensis组寄生虫和 基因重组可能发生在 昆虫媒介中与利什曼原虫相关的类型。一个新的 已发现的沙蝇细胞质多聚病毒也将 作为一种可能的生防剂进行了表征和评价 治疗利什曼病。

The objective of this project is to study the biology of human pathogenic Leishmania in their phlebotomine sandfly vectors. The project involves the disciplines of parasitology, medical entomology, genetics, virology, biochemistry and immunology. Laboratory-reared sandflies will be experimentally infected, with a number of different Leishmania types and the following aspects of the parasites biology in the insects will be studied: the role of sugars in the enhancement or inhibition of leishmanial infection in sandflies, the effect of avian blood on the parasite infection in the vector, the genetic basis of vector competence in sandflies, biochemical and morphological studies of the sandfly hind gut and its role in the transmission of Le. braziliensis group parasites, and the possibility that genetic recombination might occur among related Leishmania types in the insect vector. A newly discovered sandfly cytoplasmic polyhydrosis virus will also be characterized and evaluated as a possible biological control agent for leishmaniasis.