Adaptation of respiratory chemoreception: role of inhibitory neuropeptides

呼吸化学感受的适应：抑制性神经肽的作用

• 批准号: DP180101890
• 负责人: Dr Natasha Kumar
• 金额: $ 27.91万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-06-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP180101890
• 关键词: Adaptation; respiratory; chemoreception; role; inhibitory

The project aims to investigate how the retrotrapezoid nucleus (RTN) is involved in respiratory adaptation to hypercapnia. Chemoreceptor neurons in the RTN are crucial for life however, the mechanisms that underlie their basal and stimulated activity, to control breathing, remain to be clarified. This project will investigate the role of galanin in RTN-mediated regulation of breathing. The project looks to determine instructive and multifunctional roles of peptidergic chemosensory neurons and their contribution to local inhibitory control of the respiratory network. New knowledge from the project may in the future assist translational research into respiratory disorders and lead to technological advances.

该项目的目的是研究如何在后斜方核（RTN）参与呼吸适应高碳酸血症。RTN中的化学感受器神经元对生命至关重要，然而，其基础和刺激活动的机制，以控制呼吸，仍有待澄清。本项目将研究甘丙肽在RTN介导的呼吸调节中的作用。该项目旨在确定肽能化学感觉神经元的指导性和多功能作用及其对呼吸网络局部抑制控制的贡献。该项目的新知识可能在未来有助于呼吸系统疾病的转化研究，并导致技术进步。