IMMUNOPATHOLOGY OF MYCOBACTERIUM INTRACELLULARE IN AIDS

获得性免疫缺陷综合征(AIDS)已经成为 最近发现的最严重的疾病。艾滋病患者， 它的免疫力因人类感染而急剧下降 免疫缺陷病毒(HIV)患上更严重的疾病 由几种机会主义感染造成的快速宿命论后果。 在这些感染中，最严重的是由 禽分枝杆菌复合体(MAC)，本研究利用该复合体 该项目是相关的。建立了主投资人(PI) 米色小鼠(C57B1/bgJ/bgJ)是最敏感的 在所研究的几个品系中，小鼠品系对MAC的感染。 米色小鼠患上晚期急性MAC疾病，与 静脉、充气、腹膜、口服后的死亡率 以及直肠内挑战，有证据表明疾病增加 在单次曝光的多重挑战之后。特别的 与男同性恋者的生活方式有关，绝大多数 艾滋病患者，是单一和多重挑战，通过 直肠内途径。PI还表明，米色的老鼠是 在许多免疫病理特征上与艾滋病患者相似。 使用单一和多个静脉和直肠内挑战 具有毒性的MAC，含有抗药性标记，米色 和亲本C57B1/6小鼠，这项调查探索了为什么 在31个血清型中，有3个血清型为1、4和8型 环境是导致艾滋病患者MAC病的主要原因。同样， 这些研究询问为什么所有从艾滋病中分离出来的MAC菌株 患者拥有质粒，而只有5%的环境 菌株就是这样做的。在已知和既定的基础上发展 褐鼠的免疫生物学特征，这些研究 检查为什么这种小鼠品系对MAC最敏感 挑战。米色无自然杀伤(NK)细胞活性 在这些研究中，老鼠被给予了很大的考虑。最后，这一点 该项目设想对米色小鼠进行几种免疫调节 使用免疫抑制和免疫增强剂， 特别针对NK细胞活性。人们希望， 其中许多研究将在以下方面提供重要线索 艾滋病患者MAC病的免疫病理学及免疫治疗 艾滋病患者对MAC病的防治。

Acquired immune deficiency syndrome (AIDS) has emerged as the most serious disease discovered in recent times. AIDS patients, whose immunity is drastically reduced by infection by the human immune deficiency virus (HIV) get more serious diseases with rapid fatalistic consequences, by several opportunistic infections. Most serious among these infections are those caused by Mycobacterium aviuim complex (MAC), with which this research project is concerned. The principal invesigator (PI) established that the beige mouse (C57B1/bgJ/bgJ) to be the most susceptibel mouse strain among several strains studied, to MAC infections. Beige mice get advanced acute MAC disease, with associated mortality, following intravenous, aerogenic, intraperitoneal, oral and intrarectal challenges, with evidence of increased disease following mulitple challenges over single exposures. Of particular relevance to the lifestyle of homosexual men, the vast majority of AIDS patients, are the single and multiple challenges via the intrarectal route. The PI had also shown that beige mice are similar to AIDS patients in many immunopathological features. Using single and multiple, intravenous and intrarectal challenges with virulent MAC, containing drug resistance markers, of beige and the parent C57B1/6 mice, this investigation explores why only 3 serotypes 1,4 and 8, among the 31 serotypes occurring in the evnironment are causing MAC disease in AIDS patients. Likewise, these studies inquire why all the MAC strains isolated from AIDS patients possessed plasmids, while only 5% of the environmental strains do so. Developing on the known and established immunobiological features of beige mice, these investigations examine why this mouse strain is most susceptible to MAC challenges. Absence of natural killer (NK) cell activity in beige mice is given great consideration in these studies. Finally, this project envisages several immunomodulations of the beige mice using immunosuppressive and immunopotentiating agents, specifically directed against NK cell activity. It is hoped that many of these studies will give important leads on the immunopathology of MAC disease in AIDS and immunotherapy of AIDS patients against MAC disease.