IMMUNOPATHOLOGY OF MYCOBACTERIUM INTRACELLULARE IN AIDS

获得性免疫缺陷综合症（艾滋病）已成为 最近发现的最严重的疾病。 艾滋病患者， 其免疫力因人类感染而急剧下降， 免疫缺陷病毒（艾滋病毒）得到更严重的疾病， 快速的宿命的后果，由几个机会性感染。 这些感染中最严重的是那些由 鸟分枝杆菌复合体（MAC），本研究 项目有关。 主要研究者（PI）成立 米色小鼠（C57B1/bgJ/bgJ）是最具遗传多样性的 小鼠品系中的几个菌株研究，MAC感染。 Beige小鼠患有晚期急性MAC疾病， 死亡率，静脉注射、产气、腹膜内、口服 和直肠内挑战，有证据表明疾病增加 在经历了多次挑战后， 特别 与同性恋男性的生活方式有关，绝大多数 艾滋病患者，都是通过单一和多重的挑战， 直肠内途径。 PI还表明，米色小鼠 在许多免疫病理学特征上与艾滋病患者相似。 使用单次和多次、静脉内和直肠内激发 带有毒力MAC，含有耐药性标记，米色 和亲本C57B1/6小鼠，这项研究探讨了为什么只有 在31种血清型中， 艾滋病患者的MAC病是由evnirresistant引起的。 同样地， 这些研究探讨了为什么所有从艾滋病中分离出来的MAC菌株 患者携带质粒，而只有5%的环境 菌株确实如此。 在已知和已建立的 米色小鼠的免疫生物学特征，这些调查 研究为什么这种小鼠品系对MAC最敏感 挑战 米色中缺乏自然杀伤（NK）细胞活性 小鼠在这些研究中得到了很大的考虑。 最后 该项目设想了几种米色小鼠的免疫调节 使用免疫抑制剂和免疫增强剂， 专门针对NK细胞活性。 人们希望 这些研究中的许多将提供重要的线索， 艾滋病MAC病免疫病理及免疫治疗 艾滋病患者对抗MAC病。

Acquired immune deficiency syndrome (AIDS) has emerged as the most serious disease discovered in recent times. AIDS patients, whose immunity is drastically reduced by infection by the human immune deficiency virus (HIV) get more serious diseases with rapid fatalistic consequences, by several opportunistic infections. Most serious among these infections are those caused by Mycobacterium aviuim complex (MAC), with which this research project is concerned. The principal invesigator (PI) established that the beige mouse (C57B1/bgJ/bgJ) to be the most susceptibel mouse strain among several strains studied, to MAC infections. Beige mice get advanced acute MAC disease, with associated mortality, following intravenous, aerogenic, intraperitoneal, oral and intrarectal challenges, with evidence of increased disease following mulitple challenges over single exposures. Of particular relevance to the lifestyle of homosexual men, the vast majority of AIDS patients, are the single and multiple challenges via the intrarectal route. The PI had also shown that beige mice are similar to AIDS patients in many immunopathological features. Using single and multiple, intravenous and intrarectal challenges with virulent MAC, containing drug resistance markers, of beige and the parent C57B1/6 mice, this investigation explores why only 3 serotypes 1,4 and 8, among the 31 serotypes occurring in the evnironment are causing MAC disease in AIDS patients. Likewise, these studies inquire why all the MAC strains isolated from AIDS patients possessed plasmids, while only 5% of the environmental strains do so. Developing on the known and established immunobiological features of beige mice, these investigations examine why this mouse strain is most susceptible to MAC challenges. Absence of natural killer (NK) cell activity in beige mice is given great consideration in these studies. Finally, this project envisages several immunomodulations of the beige mice using immunosuppressive and immunopotentiating agents, specifically directed against NK cell activity. It is hoped that many of these studies will give important leads on the immunopathology of MAC disease in AIDS and immunotherapy of AIDS patients against MAC disease.