PROTAMINE HYPERSENSITIVITY AND HEPARIN FRAGMENT BIOLOGY

鱼精蛋白过敏和肝素片段生物学

基本信息

  • 批准号:
    3133318
  • 负责人:
  • 金额:
    $ 11.82万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    1985
  • 资助国家:
    美国
  • 起止时间:
    1985-09-30 至 1988-11-30
  • 项目状态:
    已结题

项目摘要

Heparin and Protamine Sulfate are charged substances which are widely used clinically. Recently it has been appreciated that protamine may cause serious adverse reactions when it is given to reserve the anticoagulant effects of heparin. In the first part of this project, we will examine the mechanism by which protamene may exert these reactions. We will study whether they are due to Type I hypersensitivity and/or whether the effect may be mediated through complement. We will examine the prevalence of positive immediate or delayed skin tests and IgG and IgE anti-protamine in patients who have received protamine containing insulin; in diabetics who have not received protamine containing insulin; in men who have had vasectomy; in other patients who have received protamine; in patients with Type I hypersensitivity to fish; and in a normal population. We will determine the true incidence and the mechanism(s) of hypersensitivity to protamine when the drug is given, to reverse the anticoagulant effect of heparin, to patients who will undergo cardiac catheterization and to patients who will undergo open heart surgery. In the second part of the project, we will examine heparin more fully to determine the Structure Activity Relationship between its fragments and complements. We will study the following polysaccharide mixtures to see which fragments are active in regulating complement: tetrasaccharides, hexasaccharide, octasaccharide, decasaccharide and larger polysaccharides. We will search for heparin fragments of very low MW which have the minimum structure necessary to regulate complement as actively as does commercial heparin. We will examine other heparin-like molecules to determine if they are able to exert the same effects on complement. We will examine other polycations to determine whether they have the same effect. Finally, we will determine if Major Basic Protein, an important constitutent of the eosinophil, may similarly modulate the complement system.
肝素和硫酸鱼精蛋白是广泛使用的带电物质 从临床上看。最近,人们意识到鱼精蛋白可能会导致 使用预留抗凝剂时出现严重不良反应 肝素的作用。在本项目的第一部分中,我们将研究 鱼精蛋白可以进行这些反应的机制。我们会研究 无论它们是由于I型超敏反应和/或 可能通过补体来调节。我们将检查流行性出血热 即刻或延迟皮肤试验和抗鱼精蛋白免疫球蛋白和IgE抗体阳性 接受了含有胰岛素的鱼精蛋白的患者;糖尿病患者 没有接受过含有胰岛素的鱼精蛋白; 输精管结扎术;其他接受过鱼精蛋白的患者; I型对鱼过敏;在正常人群中。我们会 确定超敏反应的真实发生率和机制(S) 给药时给予鱼精蛋白,以逆转其抗凝作用 肝素,给将接受心导管插入术的患者和 将接受心脏直视手术的患者。在第二部分中, 项目,我们将更全面地检查肝素以确定其结构 其片段与补体之间的活性关系。我们会研究 下面的多糖混合物,看看哪些片段是有效的 调节补体:四糖、六糖、八糖、 脱糖和较大的多糖。我们将寻找肝素 具有所需的最小结构的极低分子量碎片 像商业肝素一样积极地调节补体。我们会 检查其他类肝素分子以确定它们是否能够发挥作用 对补体也有同样的影响。我们将研究其他聚阳离子以 确定它们是否具有相同的效果。最后,我们将确定是否 主要碱性蛋白,嗜酸性粒细胞的重要组成部分,可能 类似地,调整补体系统。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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John M Weiler其他文献

Heparin, Chemically Modified Heparins, and Acharan Sulfate Differentially Regulate Complement Activity
肝素、化学修饰肝素和阿加兰硫酸盐对补体活性有不同的调节作用
  • DOI:
    10.1203/00006450-199904020-00137
  • 发表时间:
    1999-04-01
  • 期刊:
  • 影响因子:
    3.100
  • 作者:
    R Erick Edens;Yeong S Kim;Song J Wu;Robert J Linhardt;Elizabeth B Caldwell;John M Weiler
  • 通讯作者:
    John M Weiler
A World Allergy Organization international survey on physical activity as a treatment option for asthma and allergies
  • DOI:
    10.1186/1939-4551-7-34
  • 发表时间:
    2014-01-01
  • 期刊:
  • 影响因子:
  • 作者:
    Andre Moreira;Matteo Bonini;Ruby Pawankar;Sandra D Anderson;Kai-Håkon Carlsen;Christopher Randolph;William Silvers;William Storms;John M Weiler;Sergio Bonini
  • 通讯作者:
    Sergio Bonini
Azelastine Nasal Spray as Adjunctive Therapy to Azelastine Tablets in the Management of Seasonal Allergic Rhinitis
  • DOI:
    10.1016/s1081-1206(10)63023-2
  • 发表时间:
    1997-10-01
  • 期刊:
  • 影响因子:
  • 作者:
    John M Weiler;Eli O Meltzer
  • 通讯作者:
    Eli O Meltzer

John M Weiler的其他文献

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{{ truncateString('John M Weiler', 18)}}的其他基金

HEPARIN PROPHYLAXIS OF HAE EXACERBATIONS
肝素预防 HAE 加重
  • 批准号:
    6114722
  • 财政年份:
    1998
  • 资助金额:
    $ 11.82万
  • 项目类别:
HEPARIN PROPHYLAXIS OF HAE EXACERBATIONS
肝素预防 HAE 加重
  • 批准号:
    6245833
  • 财政年份:
    1997
  • 资助金额:
    $ 11.82万
  • 项目类别:
HEPARIN PROPHYLAXIS OF HAE EXACERBATIONS
肝素预防 HAE 加重
  • 批准号:
    6275957
  • 财政年份:
    1997
  • 资助金额:
    $ 11.82万
  • 项目类别:
FEXOFENDINE, DIPHENHYDRAMINE, AND ALCOHOL ON DRIVING PERFORMANCE
非索芬定、苯海拉明和酒精对驾驶性能的影响
  • 批准号:
    6276032
  • 财政年份:
    1997
  • 资助金额:
    $ 11.82万
  • 项目类别:
MODERNIZATION OF AMINO ACID ANALYZER
氨基酸分析仪的现代化
  • 批准号:
    3520359
  • 财政年份:
    1989
  • 资助金额:
    $ 11.82万
  • 项目类别:
PROTAMINE HYPERSENSITIVITY AND POLYON BIOLOGY
鱼精蛋白过敏和 Polyon 生物学
  • 批准号:
    3133320
  • 财政年份:
    1985
  • 资助金额:
    $ 11.82万
  • 项目类别:
PROTAMINE HYPERSENSITIVITY AND POLYION BIOLOGY
鱼精蛋白过敏和多离子生物学
  • 批准号:
    3133321
  • 财政年份:
    1985
  • 资助金额:
    $ 11.82万
  • 项目类别:
PROTAMINE HYPERSENSITIVITY AND POLYON BIOLOGY
鱼精蛋白过敏和 Polyon 生物学
  • 批准号:
    3133314
  • 财政年份:
    1985
  • 资助金额:
    $ 11.82万
  • 项目类别:
PROTAMINE HYPERSENSITIVITY AND HEPARIN FRAGMENT BIOLOGY
鱼精蛋白过敏和肝素片段生物学
  • 批准号:
    3133319
  • 财政年份:
    1985
  • 资助金额:
    $ 11.82万
  • 项目类别:
PROTAMINE HYPERSENSITIVITY AND HEPARIN FRAGMENT BIOLOGY
鱼精蛋白过敏和肝素片段生物学
  • 批准号:
    3133310
  • 财政年份:
    1985
  • 资助金额:
    $ 11.82万
  • 项目类别:

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  • 批准号:
    1726630
  • 财政年份:
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  • 资助金额:
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  • 项目类别:
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