EFFECT OF DIET AND PHYSICAL ACTIVITY ON PEAK BONE MASS

饮食和身体活动对峰值骨量的影响

• 批准号: 3156309
• 负责人: ROBERT Roy RECKER
• 金额: $ 10.28万
• 依托单位: CREIGHTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1984
• 资助国家: 美国
• 起止时间: 1984-06-01 至 1989-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3156309
• 关键词: alcoholic beverage consumption; body physical activity; bone density; caffeine; dietary calcium; dietary constituent; dietary proteins; dietary trace element; exercise; female; human subject; longitudinal human study; nutrition related tag; osteoporosis; phosphorus; postmenopause; young adult human (21-34)

Two hundred healthy women between ages 20 and 25 will be recruited from the first year classes in the Creighton University Schools of Medicine, Dentistry and Law. Each will be observed for a period of four years in order to test the hypothesis that calcium intake measurably influences the peak adult bone mass achieved after cessation of growth. The effect of other nutrients such as protein, phosphorus, alcohol and caffeine on this consolidation of bone mass will also be tested along with the effect of various self-chosen levels of physical activity. Dietary evaluations will be made at three-month intervals throughout the study and bone mass measurements by radio-grammetry, single photon absorptiometry and dual photon absorptiometry will be made at six-month intervals. Physical activity will be measured at six-month intervals using an activity monitor worn on the wrist for a seven-day period. We hope to confirm the findings of other studies of increased bone mass occurring after cessation of linear growth and to define the determinants of this increased mass. Thus, we hope to be able to show that peak skeletal mass is influenced by non-genetic factors, amenable to intervention early in life in a manner that can result in higher skeletal mass prior at the time when age-related bone loss begins at about age 40. This could result in greater skeletal mass remaining in old age and could offer protection from the crippling fractures of postmenopausal osteoporosis which afflicts nearly one half of our Caucasian women in their later years.

将从该中心招募200名年龄在20至25岁之间的健康女性 克赖顿大学医学院一年级课程， 牙科和法律。 每一项都将被观察四年 为了检验钙摄入量显着影响的假设 生长停止后达到的成人骨量峰值。 的效果 其他营养素，如蛋白质、磷、酒精和咖啡因 骨量的巩固也将与以下效果一起进行测试 各种自我选择的身体活动水平。 饮食评估将 在整个研究过程中每隔三个月进行一次骨量测定 通过射电测量法、单光子吸收法和双光子吸收法进行测量 光子吸收测定法将每隔六个月进行一次。 身体的 将使用活动监视器每隔六个月测量一次活动 戴在手腕上，为期 7 天。 我们希望证实调查结果 停止线性运动后骨量增加的其他研究 增长并定义质量增加的决定因素。 因此，我们 希望能够证明骨骼质量峰值受到以下因素的影响 非遗传因素，可以在生命早期以某种方式进行干预 这可能会导致与年龄相关的时候骨骼质量更高 骨质流失从 40 岁左右开始。这可能会导致骨骼更大 老年时剩余的质量可以提供保护免受残废 绝经后骨质疏松症造成的骨折，影响了近一半的人 我们晚年的白人妇女。