THE EPIDEMIOLOGY OF BONE LOSS & ACTIVITY IN MENOPAUSE

骨质流失的流行病学

• 批准号: 3155164
• 负责人: RIVKA B SANDLER
• 金额: $ 8.35万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 1979
• 资助国家: 美国
• 起止时间: 1979-05-01 至 1988-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3155164
• 关键词: aging; body physical activity; bone density; bone imaging /visualization /scanning; computed axial tomography; dietary calcium; dietary proteins; disease /disorder prevention /control; disease /disorder proneness /risk; exercise; female; human middle age (35-64); human old age (65+); human subject; human therapy evaluation; lifestyle; longitudinal human study; musculoskeletal disorder diagnosis; nutrient intake activity; nutrition related tag; osteoporosis; postmenopause; psychobiology; radiodiagnosis; sex hormones

Osteoporosis cannot be reversed nor cured, therefore it needs to be prevented. In fashioning preventive strategies the multifactorial genesis of the condition must be considered. This epidemiological study addresses the issue of the many bone determinants with special emphasis on mild levels of physical activity as a likely moderator of bone loss. The clinical trial, for which this continuation is requested, involves 255 post-menopausal women, 57 years of age at entry. The women were randomized into two groups: the walking and the control groups. Walking was selected as an intervention tool, because it is a mode of activity applicable to the broadest segments of population including the aged and the frail. The women will be followed for five years of annual cycles of assessments, during which morphometric variables, activity levels, nutritional intake will be evaluated; also, measures of cortical bone, determined with a CT scanner at the shaft of the radius, will be taken. The specific aims of the study are: 1) to find whether moderate physical activity, typified by walking, can slow the rate of age-related bone loss (ABL); 2) to define the determinants, physical activity included, of the natural history of ABL and their relative roles in bone changes over time; 3) to attempt, in the final year of the study, to define the profile of the woman at a higher than average risk of developing osteoporosis. To this end "fast" and "slow" losers of bone will have in the final year serum sex hormone levels determined as well as their lumbar trabecular bone measured by Genant's QCT method. The ultimate goal is to make a contribution to a comprehensive package of preventive strategies for osteoporosis.

骨质疏松症无法逆转或治愈，因此需要 防止。 在制定预防策略时， 的条件必须加以考虑。 这项流行病学研究涉及 许多骨决定因素的问题，特别强调轻度 体力活动水平可能是骨丢失的调节剂。 要求继续进行的临床试验涉及255名 绝经后女性，入组时年龄为57岁。 这些女性被随机分组 分为两组：步行组和对照组。 行走被选中 作为一种干预工具，因为它是一种适用于 最广泛的人群，包括老年人和体弱者。 这些妇女将被跟踪五年的年度评估周期， 在此期间，形态学变量，活动水平，营养摄入 将进行评价;此外，测量皮质骨，用CT确定 扫描仪在轴的半径，将采取。 这项研究的具体目标是： 1)为了发现以步行为代表的适度的身体活动是否可以 减缓年龄相关性骨丢失（ABL）的速度; 2)确定包括身体活动在内的自然环境的决定因素， ABL的历史及其随时间推移在骨变化中的相对作用; 3)在研究的最后一年，试图确定 女性患骨质疏松症的风险高于平均水平。 本 结束“快”和“慢”失败者的骨将在最后一年血清性别 测定激素水平以及测量腰椎骨小梁 Genant的QCT方法。 最终目标是为一个全面的一揽子方案作出贡献， 骨质疏松症的预防策略。