EFFECT OF DIET AND PHYSICAL ACTIVITY ON PEAK BONE MASS

饮食和身体活动对峰值骨量的影响

• 批准号: 3156310
• 负责人: ROBERT Roy RECKER
• 金额: $ 10.53万
• 依托单位: CREIGHTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1984
• 资助国家: 美国
• 起止时间: 1984-06-01 至 1989-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3156310
• 关键词: alcoholic beverage consumption; body physical activity; bone density; caffeine; dietary calcium; dietary constituent; dietary proteins; dietary trace element; exercise; female; human subject; longitudinal human study; nutrition related tag; osteoporosis; phosphorus; postmenopause; young adult human (21-34)

Two hundred healthy women between ages 20 and 25 will be recruited from the first year classes in the Creighton University Schools of Medicine, Dentistry and Law. Each will be observed for a period of four years in order to test the hypothesis that calcium intake measurably influences the peak adult bone mass achieved after cessation of growth. The effect of other nutrients such as protein, phosphorus, alcohol and caffeine on this consolidation of bone mass will also be tested along with the effect of various self-chosen levels of physical activity. Dietary evaluations will be made at three-month intervals throughout the study and bone mass measurements by radio-grammetry, single photon absorptiometry and dual photon absorptiometry will be made at six-month intervals. Physical activity will be measured at six-month intervals using an activity monitor worn on the wrist for a seven-day period. We hope to confirm the findings of other studies of increased bone mass occurring after cessation of linear growth and to define the determinants of this increased mass. Thus, we hope to be able to show that peak skeletal mass is influenced by non-genetic factors, amenable to intervention early in life in a manner that can result in higher skeletal mass prior at the time when age-related bone loss begins at about age 40. This could result in greater skeletal mass remaining in old age and could offer protection from the crippling fractures of postmenopausal osteoporosis which afflicts nearly one half of our Caucasian women in their later years.

200名年龄在20到25岁之间的健康女性将从 克雷顿大学医学院一年级的学生， 牙科和法律。 每一个都将被观察四年， 为了检验钙摄入量可测量地影响 停止生长后达到的成人骨质量峰值。 的影响 其他营养素，如蛋白质，磷，酒精和咖啡因， 还将沿着测试骨质量的巩固以及 各种自我选择的体力活动水平。 饮食评估将 在整个研究期间每隔三个月进行一次， 通过放射测量法、单光子吸收法和双光子吸收法进行测量 每隔六个月进行一次光子吸收测定法。 物理 每隔六个月使用活动监测器测量活动 戴在手腕上七天 我们希望能证实这些发现 其他研究表明，停止线性运动后骨量增加， 增长，并确定这种增加的质量的决定因素。 因此我们 希望能够证明峰值骨骼质量受到 非遗传因素，可以在生命早期进行干预， 这可能会导致更高的骨骼质量之前的时间，当年龄相关的 骨质流失开始于40岁左右。 这可能会导致骨骼 大量的人仍然处于老年，可以提供保护， 绝经后骨质疏松症的骨折， 我们的白人女性在她们的晚年。