IMMOBILIZATION AND MOTION AFFECTS ON INJURED TENDONS

肌腱损伤在创伤病例中所占比例越来越大 然而肌腱的分子生物学研究 治愈被忽视了。 损伤后细胞的主要反应 肌腱是产生新的胶原蛋白和非胶原蛋白。 胶原蛋白是 这种关键的结构蛋白质使肌腱能够 抵抗张力。 胶原交联的含量和位置主要是 确定抗拉力的大小。 已知 受伤肢体的固定会导致关节僵硬， 韧带和肌腱中的顽固性粘连，影响活动性。 一个 亚稳态、可还原胶原交联的增加伴随着 迁移率 轻度运动受伤的肌腱尽早后， 手术修复有利于愈合， 可还原和稳定的吡啶啉交联可能不会形成限制 议案 肌腱细胞如何对胶原蛋白反应并调节胶原蛋白反应， 受伤，以及固定或运动如何改变这些反应？ 的 本研究的总体目标是确定结构的变化 正在愈合的肌腱中的胶原蛋白 固定或运动。 根据动物实验的结果，我们 希望将一种涉及物理和化学方法策略应用于人类医学 干预以改善肌腱愈合。

Tendon injuries constitute an increasing proportion of trauma cases reported at our hospital, yet research in the molecular biology of tendon healing has been neglected. The major responses of cells in an injured tendon is to produce new collagen and noncollagen proteins. Collagen is the key structural protein that persists, giving tendon its ability to resist tensile forces. The collagen crosslink content and location largely determine the magnitude of the resistance to tensile force. It is known that immobilization of an injured limb leads to joint stiffness and intractable adhesions in ligaments and tendons that impair mobility. An increase in metastable, reducible collagen crosslinks accompanies loss of mobility. Mild exercise of an injured tendon as early as possible after surgical repair is favorable to healing because certain metastable, reducible, and stable pyridinoline crosslinks may not form to limit motion. How do tendon cells react to and regulate the collagen response to wounding, and how does immobilization or motion alter these responses? The overall objectives of this study are to identify changes in the structure of collagen in tendons that are healing and have been subjected to immobilization or motion. Based on results of animal experimentation, we hope to apply a strategy to human medicine involving physical and chemical intervention to improve tendon healing.