PLACENTAL TRANSFER & METABOLISM OF DRUGS FOR AIDS

胎盘移植

• 批准号: 3142624
• 负责人: JOSEPH DANCIS
• 金额: $ 9.97万
• 依托单位: NEW YORK UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1989
• 资助国家: 美国
• 起止时间: 1989-05-01 至 1992-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3142624
• 关键词: AIDS therapy; adenosine; antiAIDS agent; deoxyadenosines; drug metabolism; glucose transport; high performance liquid chromatography; human tissue; nitrobenzene; perfusion; placental transfer; pregnancy circulation; thiopurine; thymidine; zidovudine

The infection of infants with AIDS generally occurs ante-or intra- partum. The logical approach to the prevention or reduction in the severity of infection is to treat the infected mother. The therapeutic agents that are currently under consideration for such use are nucleosides. It would be highly desirable to know the potential of exposure of the fetus to these agents while treating the mother. It is proposed to study in a perfusion system of human placenta the transfer and metabolism of AZT and dideoxyadenosine. Thymidine and adenosine, from which these and possible future drugs are derived, will also be studied. Efficient nucleoside transport systems have been described in cells from a variety of sources. Nothing is known about the human placenta.

婴儿感染艾滋病一般发生在出生前或出生时。 分娩的时候 预防或减少贫困的逻辑方法 感染的严重程度是治疗感染的母亲。 的 目前正在考虑用于这种疾病的治疗剂 使用的是核苷。 我们非常希望了解 治疗时胎儿暴露于这些药物的可能性 母亲 提出在人体灌注系统中进行研究 胎盘对AZT和双脱氧腺苷的转运和代谢有重要影响。 胸苷和腺苷，从这些和未来可能的药物 也将被研究。 有效的核苷转运 已经在来自各种来源的细胞中描述了系统。 对人类胎盘一无所知。