课题基金 / 基金详情

PLACENTAL TRANSFER & METABOLISM OF DRUGS FOR AIDS

PLACENTAL TRANSFER & METABOLISM OF DRUGS FOR AIDS
胎盘移植
批准号:
3142622
负责人:
JOSEPH DANCIS
金额:
$10.03万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
1989
资助国家:
美国
项目状态:
已结题
起止时间:
1989-05-01 至 1992-04-30

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中文摘要
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英文摘要
The infection of infants with AIDS generally occurs ante-or intra- partum. The logical approach to the prevention or reduction in the severity of infection is to treat the infected mother. The therapeutic agents that are currently under consideration for such use are nucleosides. It would be highly desirable to know the potential of exposure of the fetus to these agents while treating the mother. It is proposed to study in a perfusion system of human placenta the transfer and metabolism of AZT and dideoxyadenosine. Thymidine and adenosine, from which these and possible future drugs are derived, will also be studied. Efficient nucleoside transport systems have been described in cells from a variety of sources. Nothing is known about the human placenta.
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IN VITRO MODEL OF POLARIZED TROPHOBLAST
  • 批准号:
    2067164
  • 项目类别:
  • 资助金额:
    $24.28万
  • 财政年份:
    1991
  • 负责人:
    JOSEPH DANCIS
  • 依托单位:
IN VITRO MODEL OF POLARIZED TROPHOBLAST
  • 批准号:
    3147279
  • 项目类别:
  • 资助金额:
    $20.29万
  • 财政年份:
    1991
  • 负责人:
    JOSEPH DANCIS
  • 依托单位:
IN VITRO MODEL OF POLARIZED TROPHOBLAST
  • 批准号:
    3147280
  • 项目类别:
  • 资助金额:
    $23.13万
  • 财政年份:
    1991
  • 负责人:
    JOSEPH DANCIS
  • 依托单位:
TOXICITY OF AIDS DRUGS ON HUMAN PLACENTA
  • 批准号:
    3144128
  • 项目类别:
  • 资助金额:
    $11.08万
  • 财政年份:
    1989
  • 负责人:
    JOSEPH DANCIS
  • 依托单位:
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  • 依托单位:
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