Shuttling through the Blood Brain Barrier using Carbon Nanoneedles

使用碳纳米针穿越血脑屏障

• 批准号: BB/J008656/1
• 负责人: Khuloud Al-Jamal
• 金额: $ 57.66万
• 依托单位: King's College London
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2012
• 资助国家: 英国
• 起止时间: 2012 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=BB%2FJ008656%2F1
• 关键词: Shuttling; through; Blood; Brain; Barrier

A significant proportion of the population are affected by diseases of the brain, many of which have limited drug treatment. Such diseases are often difficult to clinically diagnose and treat due to the limitations of brain access. One of the principle obstacles in drug development is brain delivery of the drugs or imaging agents, that can treat the disease or enhance its diagnosis. Recently, ultra small tubular like nanomaterial made of carbon called carbon nanotubes has been developed which could serve as "rafts" that could help transport drugs into the brain or could facilitate imaging of the brain. However, at present there is lack of information about the ability and mechanisms by which these nanotubes can penetrate into the brain through the blood brain barrier. This project will utilise a cellular model of this tight membrane to investigate how these nanotubes cross the endothelial brain membrane and whether they affect its integrity.

很大一部分人口受到脑部疾病的影响，其中许多疾病的药物治疗有限。由于大脑通路的限制，这些疾病通常难以临床诊断和治疗。药物开发的主要障碍之一是药物或成像剂的脑递送，这些药物或成像剂可以治疗疾病或增强其诊断。最近，由碳制成的超小管状纳米材料（称为碳纳米管）已经开发出来，它可以作为“木筏”，帮助将药物运送到大脑中，或者促进大脑成像。然而，目前缺乏关于这些纳米管可以通过血脑屏障渗透到大脑中的能力和机制的信息。该项目将利用这种紧密膜的细胞模型来研究这些纳米管如何穿过内皮脑膜以及它们是否影响其完整性。

项目成果

Real-time monitoring of magnetic drug targeting using fibered confocal fluorescence microscopy.

• DOI: 10.1016/j.jconrel.2016.07.026
• 发表时间: 2016-12-28
• 期刊: Journal of controlled release : official journal of the Controlled Release Society
• 作者: Bai J;Wang JT;Mei KC;Al-Jamal WT;Al-Jamal KT
• 通讯作者: Al-Jamal KT

Triple-Modal Imaging of Magnetically-Targeted Nanocapsules in Solid Tumours In Vivo.

• DOI: 10.7150/thno.11918
• 发表时间: 2016
• 期刊: Theranostics
• 影响因子: 12.4
• 作者: Bai J;Wang JT;Rubio N;Protti A;Heidari H;Elgogary R;Southern P;Al-Jamal WT;Sosabowski J;Shah AM;Bals S;Pankhurst QA;Al-Jamal KT
• 通讯作者: Al-Jamal KT

Yield Optimisation of Hepatitis B Virus Core Particles in E. coli Expression System for Drug Delivery Applications.

• DOI: 10.1038/srep43160
• 发表时间: 2017-03-03
• 期刊: Scientific reports
• 影响因子: 4.6
• 作者: Bin Mohamed Suffian IF;Garcia-Maya M;Brown P;Bui T;Nishimura Y;Palermo AR;Ogino C;Kondo A;Al-Jamal KT
• 通讯作者: Al-Jamal KT