PATHOGENESIS OF RETROVIRUS INDUCED ARTHRITIS

逆转录病毒引起的关节炎的发病机制

• 批准号: 3155560
• 负责人: WILLIAM P CHEEVERS
• 金额: $ 16.04万
• 依托单位: WASHINGTON STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1981
• 资助国家: 美国
• 起止时间: 1981-02-01 至 1992-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3155560
• 关键词: Retroviridae; Retroviridae disease; autoantibody; glycoproteins; goats; human subject; immunopathology; immunosuppression; microorganism immunology; pathologic process; provirus; rheumatoid arthritis; tissue /cell culture; virus antigen; virus genetics; virus infection mechanism; virus protein

Caprine arthritis-encephalitis virus (CAEV) is a lentivirus related to the ovine maedi/visna and equine infectious anemia viruses and to the human lentivirus implicated in acquired immune deficiency syndrome. CAEV causes a complex inflammatory disease syndrome in domestic goats characterized principally by progressive arthritis in adults. The insidious course of CAE arthritis and the resultant pathology are markedly similar to the chronic human arthritides, particularly rheumatoid arthritis. CAE arthritis is caused by immunopathologic processes initiated by immune responses to the viral gp135 envelope glycoprotein. The progressive course of disease is maintained by persistent viral antigen expression in the presence of anti-viral immune responses. The objective of studies in this laboratory is to define the immunologic and virologic mechanisms involved in disease pathogenesis. This proposal will evaluate mechanisms that may contribute to persistent virus replication and disease, including (1) establishment of latently-infected cells in which viral gene expression is restricted and (2) emergence and selection of virus expressing antigenic variation of gp135. These studies may also be relevant to the development of protective immunization strategies for persistent lentiviral disease.

山羊关节炎-脑炎病毒(CAEV)是一种与慢病毒相关的病毒 对绵羊梅迪/维斯纳和马传染性贫血病毒和 与获得性免疫缺陷有关的人类慢病毒 综合症。CAEV导致一种复杂的炎症性疾病综合征 以进行性关节炎为主要特征的家山羊 在成年人身上。CAE关节炎的隐匿性病程及由此引发的 病理与慢性人类关节炎明显相似， 尤其是类风湿性关节炎。CAE关节炎由以下原因引起 由免疫反应启动的免疫病理过程 病毒gp135囊膜糖蛋白。的进步历程 疾病是由持续的病毒抗原表达维持的 抗病毒免疫反应的存在。的目标是 这个实验室的研究是为了定义免疫学和 病毒学机制参与了疾病的发病机制。这 提案将评估可能有助于持久的机制 病毒复制和疾病，包括(1)建立 潜伏感染的细胞，在其中病毒基因表达 限制和(2)表达病毒的产生和筛选 Gp135的抗原性变异。这些研究也可能是相关的 制定保护性免疫策略 持续性慢病毒病。