PATHOGENESIS OF LENTIVIRUS-INDUCED ARTHRITIS

慢病毒引起的关节炎的发病机制

• 批准号: 2078620
• 负责人: WILLIAM P CHEEVERS
• 金额: $ 10万
• 依托单位: WASHINGTON STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1992
• 资助国家: 美国
• 起止时间: 1992-09-01 至 1995-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2078620
• 关键词: Retroviridae disease; goats; immunopathology; pathologic process; rheumatoid arthritis; virus infection mechanism

This is a Shannon Award providing partial support for research projects that fall short of the assigned institute's funding range but are in the margin of excellence. The Shannon award is intended to provide support to test the feasibility of the approach; develop further tests and refine research techniques; perform secondary analysis of available data sets; or conduct discrete projects that can demonstrate the PI's research capabilities or lend additional weight to an already meritorious application. Further scientific data for the CRISP System are unavailable at this time.

这是一个为研究项目提供部分支持的香农奖 低于指定研究所的资助范围，但在 卓越边际。香农奖旨在提供支持 测试该方法的可行性；开发进一步的测试和改进 研究技术；对现有数据集进行二次分析； 或进行独立的项目，以证明PI的研究 能力或为已经功成名就的 申请。CRISP系统的进一步科学数据是 目前不可用。

项目成果

Evaluation of agar gel immunodiffusion serology using caprine and ovine lentiviral antigens for detection of antibody to caprine arthritis-encephalitis virus.

使用山羊和绵羊慢病毒抗原对琼脂凝胶免疫扩散血清学进行评估，以检测山羊关节炎脑炎病毒抗体。

• DOI: 10.1128/jcm.32.1.243-245.1994
• 发表时间: 1994
• 期刊: Journal of clinical microbiology
• 影响因子: 9.4
• 作者: KnowlesJr,DP;Evermann,JF;Shropshire,C;VanderSchalie,J;Bradway,D;Gezon,HM;Cheevers,WP
• 通讯作者: Cheevers,WP

Analysis of binding of a technetium-99m-labeled monoclonal antibody to lentivirus-infected cells.

分析锝-99m 标记的单克隆抗体与慢病毒感染细胞的结合。

• DOI: 10.1097/00004424-199011000-00006
• 发表时间: 1990
• 期刊: Investigative radiology
• 影响因子: 6.7
• 作者: Papageorges,M;Gavin,PR;Adams,DS;Cheevers,WP;Barbee,DD;Sande,RD
• 通讯作者: Sande,RD

Characterization of caprine microglial cells and in vitro infection with caprine arthritis-encephalitis lentivirus.

山羊小胶质细胞的表征和山羊关节炎脑炎慢病毒的体外感染。

• 发表时间: 1994
• 期刊: Laboratory investigation; a journal of technical methods and pathology
• 作者: Baszler,TV;Harwood,WG;Lester,KL;Davis,WC;Knowles,DP
• 通讯作者: Knowles,DP

Transmembrane protein oligomers of caprine arthritis-encephalitis lentivirus are immunodominant in goats with progressive arthritis.

山羊关节炎脑炎慢病毒的跨膜蛋白寡聚体在患有进行性关节炎的山羊中具有免疫优势。

• DOI: 10.1128/jvi.66.5.3247-3250.1992
• 发表时间: 1992
• 期刊: Journal of virology
• 影响因子: 5.4
• 作者: McGuire,TC;KnowlesJr,DP;Davis,WC;Brassfield,AL;Stem,TA;Cheevers,WP
• 通讯作者: Cheevers,WP

Recombinant gp135 envelope glycoproteins of caprine arthritis-encephalitis lentivirus variants inhibit homologous and heterologous variant-specific neutralizing antibodies.

山羊关节炎脑炎慢病毒变体的重组 gp135 包膜糖蛋白抑制同源和异源变体特异性中和抗体。

• DOI: 10.1016/0042-6822(91)90747-y
• 发表时间: 1991
• 期刊: Virology
• 影响因子: 3.7
• 作者: Lichtensteiger,CA;KnowlesJr,DP;McGuire,TC;Cheevers,WP
• 通讯作者: Cheevers,WP