CONNECTIVE TISSUE ACTIVATION IN RHEUMATIC DISEASES

风湿性疾病中的结缔组织激活

• 批准号: 3150786
• 负责人: C WILLIAM CASTOR
• 金额: $ 18.19万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 1978
• 资助国家: 美国
• 起止时间: 1978-02-01 至 1988-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3150786
• 关键词: antirheumatic agents; chemical structure function; collagenase; colorimetry; cortisol; cyclic AMP; cycloheximide; fibroblasts; granuloma; human tissue; hyaluronate; inflammation; paper chromatography; peptides; proteoglycan; rheumatism; rheumatoid arthritis; synovial fluid; synovitis; tissue /cell culture

We propose to isolate selected Connective Tissue Activating Peptides (CTAPs), and to define their chemical characteristics at a molecular level. Immunologic methods will be used to identify, localize and quantitate relevant human CTAPs in biological samples. Knowledge of the mechanisms of action of this class of regulators of connective tissue metabolism will be extended by identifying factors controlling synthesis and release of CTAPs, by defining the events occurring at the time of mediator-cell interaction, and by elucidating early consequences of activation (altered transport) as well as late events (glycosaminoglycan and proteoglycan synthesis). Relevance to rheumatic disease in man will be defined by studies of distribution and concentration of CTAPs in normal individuals and rheumatic patients, as well as by testing the therepeutic potential of selected agonists. Further, the activated human cell culture system will continue to be used as a model to test agents with potential for interdicting the inflammatory process. Our long-term objective is to sufficiently understand the mechanisms regulating connective tissue metabolism in normal man, and in degenerative and inflammatory processes, so that intelligent definitive intervention may become possible in rheumatic diseases.

我们建议分离结缔组织激活肽

项目成果

Connective tissue activation. XXXI. Identification of two molecular forms of a human mesenchymal cell-derived growth factor, connective tissue activating peptide-V.

结缔组织激活。

• DOI: 10.1002/art.1780301209
• 发表时间: 1987
• 期刊: Arthritis and rheumatism
• 作者: Cabral,AR;Castor,CW
• 通讯作者: Castor,CW

Connective tissue activation. XXX: Isoelectric point microheterogeneity of CTAP-III, a human platelet-derived growth factor.

结缔组织激活。

• DOI: 10.3181/00379727-181-42292
• 发表时间: 1986
• 期刊: Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)
• 作者: Green,MS;Hossler,PA;Castor,CW
• 通讯作者: Castor,CW

Anabolic and catabolic responses of human articular cells to growth factors.

人类关节细胞对生长因子的合成代谢和分解代谢反应。

• 发表时间: 1987
• 期刊: The Journal of rheumatology
• 作者: Castor,CW;Ragsdale,CG;Cabral,AR;Smith,EM;Aaron,BP
• 通讯作者: Aaron,BP

Connective tissue activation: stimulation of glucose transport by connective tissue activating peptide III.

结缔组织激活：结缔组织激活肽 III 刺激葡萄糖转运。

• DOI: 10.1021/bi00328a029
• 发表时间: 1985
• 期刊: Biochemistry
• 影响因子: 2.9
• 作者: Castor,CW;Furlong,AM;Carter-Su,C
• 通讯作者: Carter-Su,C

Connective tissue activation. XXV. Regulation of proteoglycan synthesis in human synovial cells.

结缔组织激活。

• DOI: 10.1002/art.1780260411
• 发表时间: 1983
• 期刊: Arthritis and rheumatism
• 作者: Castor,CW;Roberts,DJ;Hossler,PA;Bignall,MC
• 通讯作者: Bignall,MC