BIOLOGY AND CHEMISTRY OF PROCOLLAGEN IN CELL CULTURE

细胞培养中原胶原的生物学和化学

• 批准号: 3151044
• 负责人: MARVIN L TANZER
• 金额: $ 11.93万
• 依托单位: UNIVERSITY OF CONNECTICUT SCH OF MED/DNT
• 依托单位国家: 美国
• 财政年份: 1976
• 资助国家: 美国
• 起止时间: 1976-09-01 至 1986-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3151044
• 关键词: Golgi apparatus; I cell disease; analytical method; biological models; carbohydrate structure; chondrocytes; chondroitin sulfates; collagen disorder; connective tissue metabolism; connective tissue pharmacology; electron microscopy; endoplasmic reticulum; fibroblasts; genetic regulation; human tissue; inborn metabolism disorder; ionophores; low density lipoprotein; molecular pathology; mutant; orphan disease /drug; pinocytosis; proteoglycan; radiotracer; secretion; sulfation; tissue /cell culture

Investigations of the pathway of procollagen biosynthesis and processing are being carried out with cell cultures. Both normal and naturally occurring mutant cell lines are being used in these studies. Attention is being focused on intracellular and extracellular procollagens, including the fibrous proteins found in the cell layer.

前胶原蛋白的生物合成和加工途径的研究 通过细胞培养来进行。正常的和自然发生的 突变的细胞系正被用于这些研究。人们的注意力正在集中 关于细胞内和细胞外的前胶原，包括纤维蛋白 在细胞层中发现。

项目成果

Abnormal glycosylation of human cellular fibronectin in the presence of swainsonine.

苦马豆素存在下人细胞纤连蛋白的异常糖基化。

• 发表时间: 1983
• 期刊: The Journal of biological chemistry
• 作者: Arumugham,RG;Tanzer,ML
• 通讯作者: Tanzer,ML

Undersulfated beta-D-xyloside glycosaminoglycans are secreted in the presence of the ionophore monensin.

硫酸不足的 β-D-木糖苷糖胺聚糖在离子载体莫能菌素存在的情况下分泌。

• DOI: 10.1016/0014-5793(81)80546-7
• 发表时间: 1981
• 期刊: FEBS letters
• 影响因子: 3.5
• 作者: Kajiwara,T;Tanzer,ML
• 通讯作者: Tanzer,ML

Reversibility of monensin inhibition of oligosaccharide processing of human fibronectin.

莫能菌素对人纤连蛋白寡糖加工的可逆性抑制。

• DOI: 10.1016/0014-4827(84)90164-2
• 发表时间: 1984
• 期刊: Experimental cell research
• 影响因子: 3.7
• 作者: Sai,S;Tanzer,ML
• 通讯作者: Tanzer,ML

Abnormal glycosylation of human fibronectin secreted in the presence of monensin.

莫能菌素存在时分泌的人纤连蛋白糖基化异常。

• 发表时间: 1983
• 期刊: The Journal of biological chemistry
• 作者: Ledger,PW;Nishimoto,SK;Hayashi,S;Tanzer,ML
• 通讯作者: Tanzer,ML

Undersulfated proteoglycans are induced by the ionophore monensin: study of possible mechanisms.

硫酸不足的蛋白多糖由离子载体莫能菌素诱导：可能机制的研究。

• DOI: 10.1016/0003-9861(82)90007-8
• 发表时间: 1982
• 期刊: Archives of biochemistry and biophysics
• 影响因子: 3.9
• 作者: Kajiwara,T;Tanzer,ML
• 通讯作者: Tanzer,ML