FACTORS INFLUENCING SURVIVAL OF VASCULARIZED BONE GRAFTS

影响血管化骨移植存活的因素

• 批准号: 3151550
• 负责人: ANDREW J WEILAND
• 金额: $ 17.91万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1979
• 资助国家: 美国
• 起止时间: 1979-07-01 至 1987-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3151550
• 关键词: blood flow measurement; blood vessel transplantation; bone imaging /visualization /scanning; bone transplantation; cyclosporines; disease /disorder model; electron microscopy; epiphysis; genetic strain; histochemistry /cytochemistry; homologous transplantation; immunosuppressive; microangiography; muscle transplantation; musculoskeletal circulation; osteomyelitis; radiotracer; skin transplantation

This proposal seeks to: 1. Evaluate bone allograft transplantation in a genetically defined rat model in order to systemically gather fundamental immunologic information concerning transplantation of vascularized bone allografts. Protocols have been designed to identify manifestations and, perhaps, the focus of the rejection process in the graft and to determine graft-host factors that affect allograft survival. Light microscopy, electron microscopy, and enzyme histochemistry will be employed to evaluate the rejection process; attempts will be made to alter graft antigenicity and evaluate the affect of cyclosporin-A immunosuppression on graft survival with the long-term objective of developing the used of allogeneic tissue in extremity reconstruction. 2. Evaluate the efficacy of free vascularized muscle flap coverage in the treatment of chronic osteomyelitis in a canine model with the objective of clarifying the role of this technique in clinical reconstructive surgery. 3. Evaluate the growth in orthotopically and heterotopically transplanted epiphyseal plates in a primate model in order to attempt to define the possible clinical role of vascularized epiphyseal transplantation in reconstructive surgery for the treatment of radial club hand, tumors involving epithyses of long bones, and the transferring of digits from the foot to the hand for congenital or traumatic conditions in children. 4. Evaluate the feasibility of molded vascularized osteoneogenesis using a titanium chamber. The possibility of producing bone with a predetermined size and shape as well as a defined vascular nutrient stalk would greatly simplify reconstruction of segmental bone defects. The results of this technique will be compared to conventional reconstructive procedures.

本建议旨在：

项目成果

Molded Vascularized Osteoneogenesis: A Preliminary Study in Rabbits

模制血管化成骨：兔子的初步研究

• DOI: 10.1097/00006534-198512000-00008
• 发表时间: 1985
• 期刊: Plastic and Reconstructive Surgery
• 影响因子: 3.6
• 作者: H. Nettelblad;M. Randolph;L. Ostrup;A. Weiland
• 通讯作者: A. Weiland

BONE-SCINTIGRAPHY IN EVALUATING THE VIABILITY OF COMPOSITE BONE-GRAFTS REVASCULARIZED BY MICRO-VASCULAR ANASTOMOSES, CONVENTIONAL AUTOGENOUS BONE-GRAFTS, AND FREE NON-REVASCULARIZED PERIOSTEAL GRAFTS

• DOI: 10.2106/00004623-198264060-00001
• 发表时间: 1982-01-01
• 期刊: JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME
• 影响因子: 5.3
• 作者: BERGGREN, A;WEILAND, AJ;OSTRUP, LT
• 通讯作者: OSTRUP, LT

BONE-GRAFTS - A RADIOLOGIC, HISTOLOGIC, AND BIOMECHANICAL MODEL COMPARING AUTOGRAFTS, ALLOGRAFTS, AND FREE VASCULARIZED BONE-GRAFTS

• DOI: 10.1097/00006534-198409000-00006
• 发表时间: 1984-01-01
• 期刊: PLASTIC AND RECONSTRUCTIVE SURGERY
• 影响因子: 3.6
• 作者: WEILAND, AJ;PHILLIPS, TW;RANDOLPH, MA
• 通讯作者: RANDOLPH, MA

Heterotopic microvascular growth plate transplantation of the proximal fibula: an experimental canine model.

腓骨近端异位微血管生长板移植：实验犬模型。

• DOI: 10.1097/00006534-198605000-00021
• 发表时间: 1986
• 期刊: Plastic and reconstructive surgery
• 影响因子: 3.6
• 作者: Nettelblad,H;Randolph,MA;Weiland,AJ
• 通讯作者: Weiland,AJ

Free vascularized bone grafts: factors affecting their survival and ability to heal to recipient bone defects.

游离血管化骨移植物：影响其存活和修复受体骨缺损能力的因素。

• 发表时间: 1982
• 期刊: Plastic and reconstructive surgery
• 影响因子: 3.6
• 作者: Berggren,A;Weiland,AJ;Dorfman,H
• 通讯作者: Dorfman,H