SPONTANEOUS DIABETES--PATHOGENESIS AND TREATMENT

该项目的目标是研究一种自发性发作的综合征。 大鼠糖尿病，这似乎是最接近的动物模型 类似于人类的胰岛素依赖型糖尿病。初步研究表明 自身免疫很可能在发病机制中发挥作用，而且似乎 导致移植胰岛的破坏，即使排斥反应是 被阻止了。赠款的具体目的包括研究和操纵 疾病的遗传背景，并试图确认自身免疫 通过以下方式将这种情况转移到非糖尿病大鼠身上 “免疫”淋巴细胞。糖尿病和糖尿病前期大鼠已被发现患有 免疫缺陷的一些特点。我们将尝试定义 免疫缺陷的致病因素(如T细胞功能异常) 并确定它是否与糖尿病有因果关系。我们会 也调查我们观察到移植的可能原因 将正常捐赠者的骨髓移植给糖尿病易患人群 减少糖尿病的发病率。

The objective of the project is to study a syndrome of spontaneous onset diabetes in rats, which appears to be the animal model most closely resembling human insulin dependent diabetes. Preliminary studies indicate autoimmunity is very likely to play a role in pathogenesis and appears to cause destruction of transplanted pancreatic islets even if rejection is prevented. Specific aims of the grant include study and manipulation of the genetic setting of the disease and attempts to confirm the autoimmune nature by transferring the condition to non diabetic rats by means of "immune" lymphocytes. Diabetic and prediabetic rats hve been found to have some characteristics of immune deficiency. We will attempt to define the responsible factors (e.g. abnormal T cell function) in the immunodeficiency and to determine whether it is causally related to the diabetes. We will also investigate possible reasons for our observation that transplantation of bone marrow from normal donors to members of the diabetes prone stock decreases the incidence of diabetes.