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INTESTINAL PROPULSION

肠道推进

基本信息

批准号：
3151445
负责人：
WILLIAM A WEEMS
金额：
$ 6.62万
依托单位：
UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON
依托单位国家：
美国
项目类别：
财政年份：
1978
资助国家：
美国
起止时间：
1978-12-01 至 1986-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/3151445
关键词：
catecholamines cholecystokinin colon duodenum gastrins gastrointestinal motility /pressure hormone regulation /control mechanism ileum jejunum myogenesis neural information processing prostaglandin E

项目摘要

The broad objective of this proposal is to quantitatively evaluate in dynamic terms the intrinsic propulsive performance of intestinal regions of cats and to examine how this performance is controlled by interactions among neural and myogenic subsystems intrinsic to the intestine, the fluid load being propelled and extrinsic control systems. The areas of particular interest are: a) fluid propelling capability of intestinal segments into an attached evaluation system having negligible resistance and constant capacitance, b) fluid propelling capability into an evaluation system having significant input resistance and infinite capacitance, c) propulsive behavior when conditions associated with the evaluation system vary as functions of time, properties resulting from the propulsion process, or both, d) the ability of hormone and extrinsic neural inputs to modulate propulsive performance, e) alterations of propulsive states by transmural stimulation, and f) interactions among intestinal wall motions, muscle mechanics, and propulsive behavior. The general method of approach will be to measure, in vitro, the amount of fluid propelled from the oral and aboral ends of an intestinal segment into an attached propulsion evaluation system which imposes on the segment well-defined physical conditions and permits the amount of propulsive work done in propelling a given fluid volume to be determined.

这项提案的广泛目标是对动力学术语肠区的内在推进性能猫，并研究这种性能是如何由交互控制的在肠道固有的神经和肌源性子系统中，液体被推进的负载和外部控制系统。以下方面：特别感兴趣的是：a)肠道的液体推进能力分段进入具有可以忽略的阻力的附加评价系统和恒定电容，b)流体推进能力进入评价具有显著输入电阻和无限电容的系统，c) 当与评估系统相关的条件时的推进行为随时间的变化而变化，由推进所产生的特性过程，或两者兼而有之，d)激素和外部神经输入的能力调制推进性能，e)通过以下方式改变推进状态跨壁刺激，以及f)肠壁运动之间的相互作用，肌肉力学和推进行为。方法的一般方法将在体外测量从口腔中排出的液体的量并将肠段的流产末端转化为连接的推进装置施加在分段上的明确物理的评价体系条件和允许在推进过程中完成的推进功的量给定待测定的液体体积。