PROSTAGLANDINS AND ARTICULAR CARTILAGE METABOLISM

前列腺素和关节软骨代谢

• 批准号: 3151896
• 负责人: LOUIS LIPPIELLO
• 金额: $ 8.02万
• 依托单位: UNIVERSITY OF NEBRASKA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 1980
• 资助国家: 美国
• 起止时间: 1980-09-01 至 1986-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3151896
• 关键词: arthritis; articular cartilage; chondrocytes; fatty acid metabolism; hormone biosynthesis; hormone metabolism; hormone regulation /control mechanism; inflammation; lipids; mass spectrometry; prostaglandins; synovial membrane

Prostaglandins affect cartilage metabolism in vivo and in vitro but their significance as metabolic regulators remains unknown. It is the intent of this proposal to investigate these agents as components of a system of cell control which modulates chondrocyte metabolism in response to environmental stimuli. The role of lipids and fatty acid composition of chondrocytes will be explored as factors predisposing articular cartilage to prostaglandin-mediated pathological changes. The long term goal of this research is to define the significance of prostaglandins in normal and pathophysiological articular cartilage and provide a rationale for therapeutic intervention in those circumstances whereby aberrations in prostaglandin synthesis may mediate connective tissue destruction.

前列腺素在体内外均影响软骨代谢，但对软骨代谢的影响较小