HEAT EXCHANGE IN OBESITY

肥胖的Zucker大鼠被广泛用作肥胖的模型，然而， 与其脂肪状态相关的宏观能量学尚未被 满意的分割。 总能量将由 用于测量食物能量的成年肥胖和瘦Zucker大鼠的平衡 摄入量、身体成分变化、总产热和总热量 总热量产生与身体活动分离的损失， 产热和食物摄入的热效应。 直接和 间接热量测定法以及食物摄入评估和测量 身体组成的变化。 直接使用和 间接量热法将揭示瞬态热响应的 瘦的和胖的动物适应不同的环境温度。 差异 将注意到体温损失，并与结肠温度相关 变化 最初将使用成年动物，以避免 年轻人成长的复杂因素。 我们希望测试 维持成年瘦和肥胖Zucker大鼠的能量学;这是我们的 假设有一个基本的差异，在能源平衡的 这些动物，特别是当寒冷或其他压力。 null结果 我们的调查表明， 能量平衡是在成年前成熟阶段的增长， 老鼠和正在成长和成熟的动物必须被研究-- 这是我们准备强调的。 建议的结果 研究可能是重要的，在确定相关的因素， 遗传性肥胖症和适当的建议， 这样的条件。

The obese Zucker rat is widely used as a model for obesity, yet the macroscopical energetics related to its fatty state have not been satisfactorily partitioned. Determinations will be made of total energy balance of adult obese and lean Zucker rats for measurement of food energy intake, body compositional change, total heat production, and total heat loss with separation of total heat production into physical activity, thermogenesis, and the thermic effect of food ingestion. Direct and indirect calorimetry as well as food intake assessment and the measurement of change in body composition will be employed. Use of both direct and indirect calorimetry will reveal the transient thermal responses of the lean and obese animals to different ambient temperatures. Differences in body heat loss will be noted and associated with colonic temperature changes. Adult animals will be used initially in order to avoid the complicating factor of growth in the young. We wish to test the maintenance energetics of the adult lean and obese Zucker rat; it is our hypothesis that there is a fundamental difference in the energy balance of these animals, particularly when cold or otherwise stressed. A null result of our investigations would suggest that the fundamental difference in energy balance is to be found in the preadult maturation phase of growth of the rats and growing and maturing animals must be studied--a change in emphasis that we are prepared to make. The results of the proposed research may be significant in identifying factors associated with genetically linked obesity and in appropriate suggestions for treatment of such a condition.