Regulated muscle-based thermogenesis for body temperature regulation

调节基于肌肉的生热作用以调节体温

• 批准号: DP220102018
• 负责人: Prof Bradley Launikonis
• 金额: $ 43.76万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2022
• 资助国家: 澳大利亚
• 起止时间: 2022-07-01 至 2025-06-30
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP220102018
• 关键词: Regulated; muscle; based; thermogenesis; body

Mammals maintain a constant core body temperature by generating heat in resting muscles in response to changes in the environmental temperatures. This project aims to show how the skeletal muscles that are closer to the body core contribute the majority of heat, how the muscles of the limbs have their heat generation curtailed as necessary, and how this is coordinated by the body in response to ambient temperature. Project outcomes include defining, for the first time, how heat generation in the muscles of the body is regulated. This should provide critical knowledge of mammalian evolution and ways to manipulate metabolism, which may provide ways to assist the production of meat by managing hypothermia and hyperthermia risk in agriculture.

哺乳动物通过在休息的肌肉中产生热量以响应环境温度的变化来保持恒定的核心体温。该项目旨在展示更接近身体核心的骨骼肌如何贡献大部分热量，四肢肌肉如何根据需要减少热量产生，以及身体如何协调这一点以应对环境温度。项目成果包括首次定义如何调节身体肌肉中的热量产生。这应该提供哺乳动物进化的关键知识和操纵代谢的方法，这可能提供通过管理农业中的低温和高温风险来帮助肉类生产的方法。