INTESTINAL TRANSPORT OF CARNITINE

肉碱的肠道转运

• 批准号: 3152581
• 负责人: WARD A OLSEN
• 金额: $ 7.93万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 1983
• 资助国家: 美国
• 起止时间: 1983-08-01 至 1987-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3152581
• 关键词: drug metabolism; gastrointestinal disorder chemotherapy; gastrointestinal nutrient absorption; gastrointestinal pharmacology; hemodialysis; hereditary carnitine deficiency myopathy; human subject; infant human (0-1 year); nutrition related tag; radiotracer; renal tubular transport

We propose to characterize intestinal carnitine absorption using a variety of in vitro and in vivo techniques in order to determine the mechanism of carnitine absorption at both physiologic and pharmacologic concentrations. Although oral carnitine has been successfully used to treat patients with systemic carnitine deficiency and has been proposed as therapy for a variety of other disorders, there are no published studies of carnitine absorption by the intestine. Since the recent studies which have implicated impaired renal tubular reabsorption in the pathogenesis of systemic carnitine deficiency suggest also the possibility of an associated intestinal transport defect, we will be especially concerned with comparing intestinal carnitine transport between normal controls and patients with that disorder. Our study may well provide important information bearing on the pathophysiology of this disease.

我们建议使用各种表征肠道肉毒碱吸收 体外和体内技术，以确定 生理和药理浓度下的肉毒碱吸收。 虽然口服肉毒碱已成功地用于治疗患者 系统性肉毒碱缺乏症，并已提出作为治疗 各种其他疾病，没有发表的研究肉碱 通过肠道吸收。 由于最近的研究， 肾小管重吸收受损可能是 全身性肉毒碱缺乏也表明相关的可能性， 肠运输缺陷，我们将特别关注比较 正常人和糖尿病患者肠道肉毒碱转运的研究 这种混乱。 我们的研究很可能提供重要的信息， 这种疾病的病理生理学。