INTESTINAL MUCOSAL FUNCTION IN DIABETES

糖尿病的肠粘膜功能

• 批准号: 3225164
• 负责人: WARD A OLSEN
• 金额: $ 4.59万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 1976
• 资助国家: 美国
• 起止时间: 1976-06-15 至 1987-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3225164
• 关键词: active transport; alpha glucosidase; beta fructofuranosidase; biological transport; brush border membrane; carbohydrate metabolism; cell membrane; gastrointestinal nutrient absorption; glucose tolerance test; human subject; hydrolase; hypoglycemic agents; ileum; intestinal mucosa; intestinal villi; jejunum; lysosomes; membrane lipids; nutrition related tag; pancreas enzyme; pancreatitis; radiotracer

We are studying the mechanisms by which experimental diabetes alters the function of the intestinal brush border membrane. We have previously shown that the stimulation of intestinal sucrase activity occurs because of impairment of enzyme protein degradation. During the next year we will study the lipid composition of the brush border membrane in an effort to explain the altered degradation of enzyme protein.

我们正在研究实验性糖尿病改变 肠刷状缘膜的功能。 我们之前已经证明， 肠道蔗糖酶活性的刺激是由于 酶蛋白降解 在接下来的一年里，我们将研究脂质 刷状缘膜的组成，以解释改变的 酶蛋白降解。