REGULATION OF URINARY ACIDIFICATION

尿液酸化的调节

• 批准号: 3154522
• 负责人: NEIL A KURTZMAN
• 金额: $ 19.95万
• 依托单位: TEXAS TECH UNIVERSITY HEALTH SCIS CENTER
• 依托单位国家: 美国
• 财政年份: 1985
• 资助国家: 美国
• 起止时间: 1985-01-01 至 1986-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3154522
• 关键词: acetazolamide; acid base balance; acidity /alkalinity; adenosine triphosphate; alkalosis; amiloride; ammonia; bicarbonates; biological fluid transport; body fluid balance therapy; calcium disorder; chronic disease /disorder; controlled environment chamber; dietary mineral; dietary trace element; hyperparathyroidism; intracellular; ion transport; kidney pharmacology; lithium; longitudinal animal study; membrane permeability; micropuncture; mineralocorticoids; nuclear magnetic resonance spectroscopy; nutrient interaction; nutrition related tag; parathyroid hormones; parathyroidectomy; phosphates; phosphorus metabolism disorders; renal failure; renal tubular transport; renal tubule; respiratory acidosis; urinary bladder; urine acidity; vanadium

This proposal describes a series of studies designed to examine a family of issues central to the control of urinary acidification. Using conventional clearance techniques we will evaluate the role of alterations in diet and blood pH as modulaters of urinary acidification. In addition, some of the factors controlling extrarenal buffering will be examined. By studying in vitro acidification using the turtle bladder and in vitro sodium and water transport using the toad bladder we plan to examine some of the mechanisms controlling urinary acidification as well as studying the effect of altered acid-base composition on water transport. In a series of complementary studies we will examine the effect of those maneuvers which alter the function of these membranes on intracellular pH or ATP content. These studies will be performed using the technique of nuclear magnetic resonance. This technique has the great advantage over other techniques designed to measure these variables in that it can be applied sequentially in living membranes under experimental conditions similar to those in which the transport characteristics of these membranes are observed.

该提案描述了一系列研究，旨在检查一个家庭， 控制尿酸化的核心问题。 使用常规 清除技术，我们将评估饮食和血液变化的作用 pH作为尿酸化的调节剂。 此外，一些因素 将检查控制肾外缓冲。 通过体外研究 利用乌龟膀胱的酸化和体外钠和水转运 利用蟾蜍膀胱，我们计划检查一些控制机制， 尿酸化以及研究酸碱改变的影响 关于水上交通的作文 在一系列补充研究中，我们将 检查那些改变这些功能的演习的效果 细胞膜上的pH值或ATP含量。 这些研究将在 使用核磁共振技术。 这项技术具有很大的 与其他旨在测量这些变量的技术相比， 在实验条件下可以顺序应用于活体膜 类似于其中这些膜的传输特性 观察

项目成果

The anemia of chronic renal failure.

慢性肾功能衰竭的贫血。

• 发表时间: 1985
• 期刊: Seminars in nephrology
• 影响因子: 3.3
• 作者: Anagnostou,A;Kurtzman,NA
• 通讯作者: Kurtzman,NA

Intact ability to lower urine pH in nonacidotic adrenalectomized rats.

降低非酸中毒肾上腺切除大鼠尿液 pH 值的完整能力。

• 发表时间: 1986
• 期刊: Mineral and electrolyte metabolism
• 作者: Mujais,SK;Nascimento,L;Rademacher,DR;Wilson,A;Kurtzman,NA
• 通讯作者: Kurtzman,NA

Nephrotic syndrome and renal failure associated with a novel glycolipid storage disorder.

与新型糖脂贮积症相关的肾病综合征和肾功能衰竭。

• DOI: 10.1159/000167608
• 发表时间: 1988
• 期刊: American journal of nephrology
• 影响因子: 4.2
• 作者: Newsom,GD;Stanbaugh,GH;Kurtzman,NA;Brady,RO;Gal,AE;Vorstad,J
• 通讯作者: Vorstad,J

Regulation of renal Na-K-ATPase in the rat: effect of uninephrectomy.

大鼠肾 Na-K-ATP 酶的调节：单肾切除术的影响。

• DOI: 10.1152/ajprenal.1986.251.3.f506
• 发表时间: 1986
• 期刊: The American journal of physiology
• 作者: Mujais,SK;Kurtzman,NA
• 通讯作者: Kurtzman,NA