METAL RELEASE BY TOTAL REPLACEMENT PROSTHESES

全替换假体的金属释放

• 批准号: 3159369
• 负责人: Jonathan Black
• 金额: $ 17.62万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 1988
• 资助国家: 美国
• 起止时间: 1988-04-01 至 1989-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3159369
• 关键词: X ray crystallography; alloys; atomic absorption spectrometry; biomaterial development /preparation; biomaterial interface interaction; cytotoxicity; electrochemistry; hip prosthesis; joint prosthesis; laboratory rat; mass spectrometry; scanning electron microscopy

Clinical studies have shown significant release of metal bearing ionic species from total joint replacements, both acutely and in the long term. In vitro cytotoxicity and animal implantation studies suggest adverse biological roles for such released materials. However, their origin is unclear: they may be produced by uniform corrosion, or by wear and fretting during articulation or by some combination of these and other processes. A series of in vitro and in vivo studies is proposed to examine some features of metal release in the two common alloy systems in use today: cobalt-base and titanium-base. Four main experimental models are to be used: in vitro passive release, anodic release and cyclic loading and release from an in vivo rat THR. Independent experimental material parameters will include alloy composition, heat treatment and surface treatment. Analytical techniques will include atomic absorption spectroscopy (AAS), scanning electron microscopy with electron diffraction x- ray analysis (SEM/EDAX) and secondary ion mass spectroscopy (SIMS).

临床研究显示，金属轴承显著释放。 来自完全关节置换的离子物种，无论是急性还是在 从长远来看。体外细胞毒性与动物着床 研究表明，这种释放的物质具有不利的生物学作用 材料。然而，它们的来源尚不清楚：它们可能是 由均匀腐蚀或由磨损和微动产生的 发音或通过这些和其他过程的某种组合。 建议进行一系列体外和体内研究，以检验 两种常见合金体系中金属释放的一些特点 今天使用的：钴基和钛基。四个主要方面 将使用实验模型：体外被动释放， 大鼠在体阳极释放和循环负荷释放 太棒了。独立的实验材料参数将包括 合金成分、热处理和表面处理。 分析技术将包括原子吸收光谱分析 (原子吸收光谱)、扫描电子显微镜和电子衍射仪。 射线分析(SEM/EDAX)和二次离子质谱学 (模拟人生)。